Stroke remains a significant global health challenge, ranking as the second leading cause of death and the third leading cause of death and disability combined worldwide. The 2022 Global Stroke Factsheet reveals a 50% increase in the lifetime risk of stroke over the past 17 years, with 1 in 4 individuals now facing this threat [1]. The prevalence of upper limb impairment ranges from 50% to 80% in the acute phase to 40% to 50% in the chronic phase of stroke [2]. This prevalence imposes significant demands on health care systems, with rehabilitation needs far outpacing available resources, as noted by the World Health Organization [3].

Traditional therapy for hand motor recovery is highly effective, offering personalized guidance, feedback, and support for both gross and fine motor deficits. However, it is often inaccessible for patients in remote areas, costly, time-consuming, and constrained by a shortage of professionals. In addition, its repetitive nature can reduce patient motivation and adherence, underscoring the need for more engaging and scalable solutions [4].

Telerehabilitation has emerged as a promising solution, offering scalable and accessible interventions to bridge the gap between demand and supply, especially accelerated by the COVID-19 pandemic, which has catalyzed a rapid technological transformation in post–stroke rehabilitation, driving the adoption of telerehabilitation services delivered directly to the homes of stroke survivors [5]. Among these innovations, smart device–based therapy holds the promise of improving hand motor function through gamified, interactive designs that enhance engagement and adherence [6]. Smart devices, such as wearables, mobile apps, and sensor-integrated equipment, provide real-time feedback, track patient progress, and enable therapists to monitor performance remotely. Such systems often integrated gamification and virtual reality elements to improve engagement and adherence. Studies suggested that these interventions not only enhanced motor outcomes but also positively influenced psychological well-being, such as motivation and satisfaction with therapy [7].

Although there are limited data on the comparative effectiveness of smart device–based therapies, their potential in stroke rehabilitation is promising [8].

This study aimed to identify smart device–based therapy interventions for improving hand motor function in stroke survivors during rehabilitation and to assess their effectiveness in comparison with traditional therapy methods. Specifically, the study sought to identify and categorize the types of digital hand rehabilitation devices available to stroke patients, including their functionalities and applications; and to compare the effectiveness of remote smart device–based therapies with traditional rehabilitation methods in enhancing hand motor function in stroke survivors.

The research questions are as follows: What types of digital hand rehabilitation devices are available for remote use by patients with stroke, and how do their functionalities and effectiveness in improving motor function compare with traditional therapy?

The scoping review was performed according to the Joanna Briggs Institute methodology for scoping reviews [9,10] and was reported following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews; Checklist 1 ) guidelines [11].

The review was registered on the Open Science Framework [12] to promote transparency, enhance reproducibility, and ensure open access to the data, methods, and findings for the broader scientific community.

This scoping review was conducted to identify smart device–based therapy interventions in clinical trials across 7 databases. The databases searched included Web of Science, MEDLINE (via PubMed), EBSCO Complete, ScienceDirect, and Scopus. In addition, literature was retrieved using the search engine Google Scholar and the publisher platform ClinicalKey. The initial search was conducted in December 2023 for studies published between 2018 and 2023. An updated search was performed on August 10, 2025, extending the coverage to studies published from 2018 to 2025. Additional eligible studies were hand-searched. The available literature was screened to identify smart device–based therapy interventions used to improve hand motor function in stroke survivors during rehabilitation, and their levels of evidence were analyzed.

The search used the following primary keywords and corresponding Medical Subject Headings terms: “Stroke,” “Telerehabilitation,” “Smart devices,” and “Upper extremity.” The primary keywords and corresponding Medical Subject Headings terms are listed in Table 1. The search strategy was tailored to align with the specific indexing and search functionalities of each database. Adjustments were made not only to the keywords but also to the search parameters unique to each platform to ensure comprehensive retrieval of relevant studies. The full search strategy for each database is presented in Multimedia Appendix 1.

The inclusion and exclusion criteria are shown in Textbox 1.

All identified references were managed using Mendeley (v 1.19.8; Elsevier), and duplicate records were removed using Covidence systematic review software (Veritas Health Innovation). The study selection process followed a structured multistage approach. First, 2 independent reviewers conducted an initial screening of titles and abstracts to identify potentially relevant studies. Studies deemed ineligible based on predefined inclusion and exclusion criteria were excluded at this stage. Full-text screening was performed on the remaining studies by 2 independent reviewers to determine final eligibility. Any disagreements regarding study inclusion were resolved through discussion, and if necessary, a third reviewer provided adjudication. Covidence systematic review software was used throughout the selection process to ensure accuracy and consistency.

A structured data charting framework was developed in Covidence to ensure a systematic and organized approach to data extraction. Two independent reviewers extracted key information from the selected studies, including study characteristics (eg, author, publication year, and country), participant details (eg, sample size, stroke type, and rehabilitation setting), intervention descriptions (eg, technology type and therapy mode), and reported outcomes (eg, functional improvements). To maintain consistency and accuracy, the reviewers engaged in discussions to resolve any discrepancies in the extracted data. If disagreements persisted, a third reviewer provided adjudication. The finalized data were compiled into Microsoft Excel for further synthesis and analysis, enabling a comprehensive comparison of intervention effectiveness across studies.

For each included study, key data points were systematically extracted to facilitate a comprehensive analysis. The extracted data included the study details, study design, participant characteristics, intervention details, outcome measures, and the effectiveness of interventions.

The extracted data were systematically compiled and analyzed to generate a comprehensive overview of the characteristics and findings of the included studies. Data synthesis was carried out in multiple stages to ensure a structured and thorough evaluation. Initially, all relevant data were organized in Microsoft Excel (Microsoft Corporation), where key variables—such as study design, participant demographics, intervention type, outcome measures, and reported effectiveness—were categorized.

Quantitative findings, including the effectiveness of smart device–based therapy on hand motor function improvement, were aggregated based on standardized outcome measures, such as the FMA-UE, SIS, and WMFT. These results were interpreted to determine trends in functional improvements observed among stroke survivors who underwent smart device–based rehabilitation. In addition, variations in intervention designs—such as the use of virtual and mixed reality, gamified rehabilitation platforms, robotic-assisted devices, and wearable sensors—were examined to explore how different technological solutions contribute to rehabilitation outcomes. Consideration was also given to the mode of therapy delivery (asynchronous, synchronous, or hybrid), as well as contextual factors influencing treatment effectiveness, such as study settings (home-based vs inpatient rehabilitation) and patient characteristics (chronic vs subacute stroke).

A total of 958 records were identified from databases; after removing duplicates, 951 papers underwent screening, and following a review of titles and abstracts, 877 papers were excluded. Full texts of 74 papers were acquired for further screening. During the full paper text screening, 57 studies were excluded, and the remaining 17 [13-29] studies were selected for extraction. Figure 1 illustrates the process.

Of the 958 identified studies, 17 [13-28] met the inclusion criteria. The studies included randomized controlled trials (RCTs; n=9) [13,16,18-23,27-29], non-RCT (feasibility and experimental; n=4) [15,17,26,27], pilot and feasibility studies (n=3) [14,19,20], and comparative non-RCT (n=1) [24]. The interventions used diverse digital strategies, including gamification (n=14) [13-16,18-26,28], virtual and mixed reality devices (n=7) [14-16,18,22,23,25], Kinect camera and sensor (n=6) [13,15,16,22,23,25], Jintronix software (n=4) [15,16,22,23], robot-assisted devices (n=3) [14,20,24], and app or platform based (n=7) [15,16,22,23,25,26,29]. By stroke phase, most studies included chronic cohorts (n=12), with several spanning subacute populations (n=6); we found no acute-only trials. These studies involved 508 participants. Smart device–based interventions were delivered via asynchronous (n=6) [15,16,22,23,25,29], synchronous (n=1) [17], and hybrid (n=10) [13,14,18-21,24,26-28] approaches. Patient care settings were predominantly home-based (n=14) [13,14,16-20,22,24-29], with several studies also involving outpatient components (n=7) [14,15,17,18,23,24,27] and inpatient settings in 2 studies (n=2) [21,28]. In 3 studies, cognitive tests were used for outcome measures—Montreal Cognitive Assessment [22,27,29] and Neurobehavioral Functioning Inventory [29].

An overview of interventions and outcome of each used device of 17 included studies is summarized in Tables 2 and 3.

The scoping review highlighted the potential of smart device–based therapies in improving hand motor function among stroke survivors. The review synthesized evidence from 17 studies and identified 5 main types of digital hand rehabilitation devices: virtual and mixed reality systems [15,16,18,22,23,25], which provide immersive environments for interactive training; wearable sensor-based devices, such as motion-tracking gloves [13] and inertial measurement unit–based sensors [21,27,28], enabling real-time feedback and remote monitoring; robotic-assisted rehabilitation devices [14,19,20,24,26], which deliver mechanical support and facilitate guided movement practice; tablet- or app-based rehabilitation platforms [13,15,16,22,23,25,29], offering structured exercise programs with interactive and gamified elements; camera- or Kinect-based motion tracking systems [13,15,16,22,23,25], allowing gesture-based therapy without direct device contact; and mirror therapy device [17], representing a low-tech but adaptable telerehabilitation tool. These smart technologies enhance rehabilitation and can complement or even surpass traditional rehabilitation methods in certain contexts. In line with our findings, several recent trials have further strengthened the evidence on smart device–based and telerehabilitation approaches for upper limb recovery after stroke. For example, Pavan et al [24] demonstrated that both robotic and nonrobotic telerehabilitation models significantly improved motor and cognitive skills in subacute stroke patients, highlighting the feasibility of integrating such solutions into home-based care. Similarly, Simpson et al [27] reported that a virtually delivered program combined with a wearable device increased upper limb activity, emphasizing the role of remote therapist support and objective monitoring. Toh et al [28] further confirmed the efficacy of wearable-based interventions, where a novel Smart Reminder device improved upper limb function and adherence in a randomized controlled trial. Taken together, these results reinforce the promise of smart device–based rehabilitation and provide an important context for examining how such approaches compare directly with established traditional therapies.

Treatment effectiveness was compared with a variety of conventional or control interventions (hereafter collectively referred to as traditional therapy) in 11 studies [13,16-18,21-24,27-29]. These comparators were heterogeneous and included usual care, GRASP home programs, face-to-face mirror therapy, and conventional home exercise programs with outpatient OT or PT. FMA-UE improved across studies, with gains ranging from 6.8 to 17.56 points in experimental groups, frequently exceeding the minimal clinically important difference and indicating clinically meaningful motor recovery. Functional metrics, such as WMFT, Box and Block Test, and Action Research Arm Test, showed moderate to large improvements, with effect sizes ranging from g=0.55 to g=0.90. Cognitive outcomes were less frequently assessed, but in the few studies that did, the Montreal Cognitive Assessment demonstrated a moderate-to-large effect [22,27,29].

Although the included studies varied in design and sample size, the overall findings indicate that smart device–based interventions are both safe and feasible for telerehabilitation, either delivered independently or in combination with conventional therapy. Several systems already integrated into clinical practice, such as Jintronix [15,16,22,23], have demonstrated that commercial platforms can be effectively adapted for home-based programs, enhancing patient motivation and adherence. Other tools, including the home-based virtual rehabilitation system [25] and wearable sensor-based devices [21,27,28], showed potential to support partially autonomous rehabilitation at home by providing real-time feedback, objective monitoring, and remote therapist supervision. Robotic-assisted devices such as H-Man and iCONE [14,19,20,24] offered mechanical support for patients with more severe impairments and achieved clinically meaningful improvements even with limited therapist input.

The findings of this scoping review highlight the significant potential of smart device–based therapy for enhancing hand motor function among stroke survivors. Building on these promising outcomes, several future research directions can help advance the development, implementation, and effectiveness of these interventions. Future research should explore the integration of cognitive and hand motor function rehabilitation to address the multifaceted needs of stroke survivors. Developing comprehensive standardized rehabilitation protocols that include interventions targeting memory, attention, and executive hand function alongside motor recovery could provide a more holistic approach to therapy. In addition, the absence of a single standardized outcome measure for hand motor recovery remains a major limitation of the current evidence base, introducing variability and potential bias across studies. Future work should therefore prioritize the development and adoption of consensus-based, standardized outcome measures to allow more reliable comparison and synthesis of findings across trials.

Emerging innovations in augmented reality and artificial intelligence present exciting opportunities for advancing stroke rehabilitation [33]. Augmented reality can provide immersive, engaging therapy environments, whereas artificial intelligence–driven systems have the potential to deliver adaptive, personalized rehabilitation. In addition, research on more sophisticated sensor and feedback mechanisms can refine therapy delivery and enhance patient outcomes [34], which leads to the crucial future recommendation that technology and innovations should focus on creating user-friendly devices and protocols that empower patients to engage in effective, autonomous rehabilitation from the comfort of their homes, addressing the growing demand for accessible care.

Smart device–based interventions demonstrate possibilities in enhancing hand motor function and overall rehabilitation outcomes in stroke survivors. These results strongly advocate for the integration of smart devices into standard rehabilitation protocols to maximize accessibility and improve patient-specific outcomes. Further research and development are warranted to expand the use of smart technologies, optimize their effectiveness, and integrate them more broadly into stroke rehabilitation practices.