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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JRAT</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Rehabil Assist Technol</journal-id>
      <journal-title>JMIR Rehabilitation and Assistive Technologies</journal-title>
      <issn pub-type="epub">2369-2529</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v10i1e43615</article-id>
      <article-id pub-id-type="pmid">37253381</article-id>
      <article-id pub-id-type="doi">10.2196/43615</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Paper</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Original Paper</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Technologies in Home-Based Digital Rehabilitation: Scoping Review</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Mavragani</surname>
            <given-names>Amaryllis</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Peterson</surname>
            <given-names>Gunnel</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Perrochon</surname>
            <given-names>Anaïck</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Arntz</surname>
            <given-names>Angela</given-names>
          </name>
          <degrees>MSc</degrees>
          <xref rid="aff01" ref-type="aff">1</xref>
          <address>
            <institution>Division of Physiotherapy</institution>
            <institution>Department of Applied Health Sciences</institution>
            <institution>University of Applied Health Sciences Bochum</institution>
            <addr-line>Gesundheitscampus 6-8</addr-line>
            <addr-line>Bochum, 44801</addr-line>
            <country>Germany</country>
            <phone>49 234 77727 679</phone>
            <fax>49 234 77727 879</fax>
            <email>angela.arntz@hs-gesundheit.de</email>
          </address>
          <xref rid="aff02" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-1255-1374</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Weber</surname>
            <given-names>Franziska</given-names>
          </name>
          <degrees>MSc</degrees>
          <xref rid="aff01" ref-type="aff">1</xref>
          <xref rid="aff03" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-6226-9879</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Handgraaf</surname>
            <given-names>Marietta</given-names>
          </name>
          <degrees>MSc</degrees>
          <xref rid="aff01" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-9291-3111</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>Lällä</surname>
            <given-names>Kaisa</given-names>
          </name>
          <degrees>MSc</degrees>
          <xref rid="aff04" ref-type="aff">4</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-6153-9980</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author">
          <name name-style="western">
            <surname>Korniloff</surname>
            <given-names>Katariina</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff04" ref-type="aff">4</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-0753-1483</ext-link>
        </contrib>
        <contrib id="contrib6" contrib-type="author">
          <name name-style="western">
            <surname>Murtonen</surname>
            <given-names>Kari-Pekka</given-names>
          </name>
          <degrees>MSc</degrees>
          <xref rid="aff04" ref-type="aff">4</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-4370-1873</ext-link>
        </contrib>
        <contrib id="contrib7" contrib-type="author">
          <name name-style="western">
            <surname>Chichaeva</surname>
            <given-names>Julija</given-names>
          </name>
          <degrees>BSc</degrees>
          <xref rid="aff04" ref-type="aff">4</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-2390-0947</ext-link>
        </contrib>
        <contrib id="contrib8" contrib-type="author">
          <name name-style="western">
            <surname>Kidritsch</surname>
            <given-names>Anita</given-names>
          </name>
          <degrees>MSc</degrees>
          <xref rid="aff05" ref-type="aff">5</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-3214-0270</ext-link>
        </contrib>
        <contrib id="contrib9" contrib-type="author">
          <name name-style="western">
            <surname>Heller</surname>
            <given-names>Mario</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff06" ref-type="aff">6</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-2750-5634</ext-link>
        </contrib>
        <contrib id="contrib10" contrib-type="author">
          <name name-style="western">
            <surname>Sakellari</surname>
            <given-names>Evanthia</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff07" ref-type="aff">7</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-5396-029X</ext-link>
        </contrib>
        <contrib id="contrib11" contrib-type="author">
          <name name-style="western">
            <surname>Athanasopoulou</surname>
            <given-names>Christina</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff08" ref-type="aff">8</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-5577-1193</ext-link>
        </contrib>
        <contrib id="contrib12" contrib-type="author">
          <name name-style="western">
            <surname>Lagiou</surname>
            <given-names>Areti</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff07" ref-type="aff">7</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-6687-358X</ext-link>
        </contrib>
        <contrib id="contrib13" contrib-type="author">
          <name name-style="western">
            <surname>Tzonichaki</surname>
            <given-names>Ioanna</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff08" ref-type="aff">8</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-6623-0747</ext-link>
        </contrib>
        <contrib id="contrib14" contrib-type="author">
          <name name-style="western">
            <surname>Salinas-Bueno</surname>
            <given-names>Iosune</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff09" ref-type="aff">9</xref>
          <xref rid="aff10" ref-type="aff">10</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-1482-1056</ext-link>
        </contrib>
        <contrib id="contrib15" contrib-type="author">
          <name name-style="western">
            <surname>Martínez-Bueso</surname>
            <given-names>Pau</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff09" ref-type="aff">9</xref>
          <xref rid="aff10" ref-type="aff">10</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-0128-0265</ext-link>
        </contrib>
        <contrib id="contrib16" contrib-type="author">
          <name name-style="western">
            <surname>Velasco-Roldán</surname>
            <given-names>Olga</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff09" ref-type="aff">9</xref>
          <xref rid="aff10" ref-type="aff">10</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-2376-433X</ext-link>
        </contrib>
        <contrib id="contrib17" contrib-type="author">
          <name name-style="western">
            <surname>Schulz</surname>
            <given-names>Ralf-Joachim</given-names>
          </name>
          <degrees>MD, PhD</degrees>
          <xref rid="aff11" ref-type="aff">11</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-8844-8894</ext-link>
        </contrib>
        <contrib id="contrib18" contrib-type="author">
          <name name-style="western">
            <surname>Grüneberg</surname>
            <given-names>Christian</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff01" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-8870-8457</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff01">
        <label>1</label>
        <institution>Division of Physiotherapy</institution>
        <institution>Department of Applied Health Sciences</institution>
        <institution>University of Applied Health Sciences Bochum</institution>
        <addr-line>Bochum</addr-line>
        <country>Germany</country>
      </aff>
      <aff id="aff02">
        <label>2</label>
        <institution>Faculty of Human Sciences</institution>
        <institution>University of Cologne</institution>
        <addr-line>Cologne</addr-line>
        <country>Germany</country>
      </aff>
      <aff id="aff03">
        <label>3</label>
        <institution>Department of Rehabilitation, Physiotherapy Science &#38; Sports</institution>
        <institution>University Medical Center Utrecht</institution>
        <addr-line>Utrecht</addr-line>
        <country>Netherlands</country>
      </aff>
      <aff id="aff04">
        <label>4</label>
        <institution>Institute of Rehabilitation</institution>
        <institution>Jamk University of Applied Sciences</institution>
        <addr-line>Jyväskylä</addr-line>
        <country>Finland</country>
      </aff>
      <aff id="aff05">
        <label>5</label>
        <institution>Institute of Health Sciences</institution>
        <institution>St. Pölten University of Applied Sciences</institution>
        <addr-line>St. Pölten</addr-line>
        <country>Austria</country>
      </aff>
      <aff id="aff06">
        <label>6</label>
        <institution>Department of Media &#38; Digital Technologies</institution>
        <institution>St. Pölten University of Applied Sciences</institution>
        <addr-line>St. Pölten</addr-line>
        <country>Austria</country>
      </aff>
      <aff id="aff07">
        <label>7</label>
        <institution>Department of Public and Community Health</institution>
        <institution>Laboratory of Hygiene and Epidemiology</institution>
        <institution>University of West Attica</institution>
        <addr-line>Athens</addr-line>
        <country>Greece</country>
      </aff>
      <aff id="aff08">
        <label>8</label>
        <institution>Department of Occupational Therapy</institution>
        <institution>University of West Attica</institution>
        <addr-line>Athens</addr-line>
        <country>Greece</country>
      </aff>
      <aff id="aff09">
        <label>9</label>
        <institution>Health Research Institute of the Balearic Islands (IdISBa)</institution>
        <addr-line>Palma de Mallorca</addr-line>
        <country>Spain</country>
      </aff>
      <aff id="aff10">
        <label>10</label>
        <institution>Department of Nursing and Physiotherapy</institution>
        <institution>University of the Balearic Islands</institution>
        <addr-line>Palma de Mallorca</addr-line>
        <country>Spain</country>
      </aff>
      <aff id="aff11">
        <label>11</label>
        <institution>Department of Geriatric Medicine</institution>
        <institution>St. Marien-Hospital</institution>
        <addr-line>Cologne</addr-line>
        <country>Germany</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Angela Arntz <email>angela.arntz@hs-gesundheit.de</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2023</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>27</day>
        <month>7</month>
        <year>2023</year>
      </pub-date>
      <volume>10</volume>
      <elocation-id>e43615</elocation-id>
      <history>
        <date date-type="received">
          <day>18</day>
          <month>10</month>
          <year>2022</year>
        </date>
        <date date-type="rev-request">
          <day>12</day>
          <month>1</month>
          <year>2023</year>
        </date>
        <date date-type="rev-recd">
          <day>10</day>
          <month>3</month>
          <year>2023</year>
        </date>
        <date date-type="accepted">
          <day>25</day>
          <month>5</month>
          <year>2023</year>
        </date>
      </history>
      <copyright-statement>©Angela Arntz, Franziska Weber, Marietta Handgraaf, Kaisa Lällä, Katariina Korniloff, Kari-Pekka Murtonen, Julija Chichaeva, Anita Kidritsch, Mario Heller, Evanthia Sakellari, Christina Athanasopoulou, Areti Lagiou, Ioanna Tzonichaki, Iosune Salinas-Bueno, Pau Martínez-Bueso, Olga Velasco-Roldán, Ralf-Joachim Schulz, Christian Grüneberg. Originally published in JMIR Rehabilitation and Assistive Technology (https://rehab.jmir.org), 27.07.2023.</copyright-statement>
      <copyright-year>2023</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Rehabilitation and Assistive Technology, is properly cited. The complete bibliographic information, a link to the original publication on https://rehab.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://rehab.jmir.org/2023/1/e43615" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>Due to growing pressure on the health care system, a shift in rehabilitation to home settings is essential. However, efficient support for home-based rehabilitation is lacking. The COVID-19 pandemic has further exacerbated these challenges and has affected individuals and health care professionals during rehabilitation. Digital rehabilitation (DR) could support home-based rehabilitation. To develop and implement DR solutions that meet clients’ needs and ease the growing pressure on the health care system, it is necessary to provide an overview of existing, relevant, and future solutions shaping the constantly evolving market of technologies for home-based DR.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>In this scoping review, we aimed to identify digital technologies for home-based DR, predict new or emerging DR trends, and report on the influences of the COVID-19 pandemic on DR.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>The scoping review followed the framework of Arksey and O’Malley, with improvements made by Levac et al. A literature search was performed in PubMed, Embase, CINAHL, PsycINFO, and the Cochrane Library. The search spanned January 2015 to January 2022. A bibliometric analysis was performed to provide an overview of the included references, and a co-occurrence analysis identified the technologies for home-based DR. A full-text analysis of all included reviews filtered the trends for home-based DR. A gray literature search supplemented the results of the review analysis and revealed the influences of the COVID-19 pandemic on the development of DR.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>A total of 2437 records were included in the bibliometric analysis and 95 in the full-text analysis, and 40 records were included as a result of the gray literature search. Sensors, robotic devices, gamification, virtual and augmented reality, and digital and mobile apps are already used in home-based DR; however, artificial intelligence and machine learning, exoskeletons, and digital and mobile apps represent new and emerging trends. Advantages and disadvantages were displayed for all technologies. The COVID-19 pandemic has led to an increased use of digital technologies as remote approaches but has not led to the development of new technologies.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>Multiple tools are available and implemented for home-based DR; however, some technologies face limitations in the application of home-based rehabilitation. However, artificial intelligence and machine learning could be instrumental in redesigning rehabilitation and addressing future challenges of the health care system, and the rehabilitation sector in particular. The results show the need for feasible and effective approaches to implement DR that meet clients’ needs and adhere to framework conditions, regardless of exceptional situations such as the COVID-19 pandemic.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>digital rehabilitation</kwd>
        <kwd>digital technologies</kwd>
        <kwd>home-based rehabilitation</kwd>
        <kwd>digital health intervention</kwd>
        <kwd>scoping review</kwd>
        <kwd>artificial intelligence</kwd>
        <kwd>AI</kwd>
        <kwd>machine learning</kwd>
        <kwd>COVID-19 pandemic</kwd>
        <kwd>mobile app</kwd>
        <kwd>remote health</kwd>
        <kwd>mobile phone</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>Rehabilitation is an essential part of caring for people with acute or chronic health conditions, impairments, or injuries that limits functioning [<xref ref-type="bibr" rid="ref1">1</xref>]. It is estimated that 2.5 billion people worldwide live with health conditions that benefit from rehabilitation [<xref ref-type="bibr" rid="ref1">1</xref>]. Owing to population growth, aging, and the increasing number of people with chronic diseases and disabilities, the need for rehabilitation is steadily increasing worldwide [<xref ref-type="bibr" rid="ref1">1</xref>].</p>
        <p>Two of the most challenging aspects of rehabilitation are the high costs of inpatient and long-term rehabilitation programs [<xref ref-type="bibr" rid="ref2">2</xref>] and the poor continuity of rehabilitation when patients are transferred to their homes [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref4">4</xref>]. To address these challenges, a shift in rehabilitation from inpatient care or rehabilitation centers to home settings is essential [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref6">6</xref>]. Therefore, various models have been developed to offer early home-based rehabilitation [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref8">8</xref>]. However, for effective home-based rehabilitation, sufficient support must be provided to clients (persons who receive health care services) and health care professionals (persons who provide health care services).</p>
        <p>Incorporating new digital technologies into rehabilitation could help to meet these demands. Digital rehabilitation (DR) can be defined as using digital technologies as a part of the rehabilitation process [<xref ref-type="bibr" rid="ref9">9</xref>]. DR aims to optimize functioning and reduce disability of individuals with health conditions in interaction with their environment [<xref ref-type="bibr" rid="ref9">9</xref>]. This includes, but is not limited to, the use of tele- and remote rehabilitation applications and services, automatic services, robot-assisted technologies, wearables, emails, video, speech, and SMS text messaging solutions [<xref ref-type="bibr" rid="ref9">9</xref>]. By using tele- and remote rehabilitation applications and services, for example, sensors and wearables, opportunities exist for monitoring clients’ health status at home [<xref ref-type="bibr" rid="ref10">10</xref>-<xref ref-type="bibr" rid="ref12">12</xref>]. In addition, DR improves rehabilitation outcomes in clients with heart failure, diabetes, and respiratory disease [<xref ref-type="bibr" rid="ref13">13</xref>]. They also help clients to manage pain; increase their physical activity; and improve mental health, diet quality, and nutrition [<xref ref-type="bibr" rid="ref13">13</xref>]. Furthermore, it appears that some parts of the DR are cost-effective [<xref ref-type="bibr" rid="ref13">13</xref>]. With the combination of commercially available technologies, Internet of Things (IoT), and artificial intelligence (AI), there is also the possibility of remote health assessments and personalized rehabilitation interventions [<xref ref-type="bibr" rid="ref14">14</xref>]. In addition, DR can have a positive impact on self-management [<xref ref-type="bibr" rid="ref15">15</xref>-<xref ref-type="bibr" rid="ref17">17</xref>]. Self-management aims to improve clients’ ability to manage their disability and improve their lifestyles. It underlines the active participation of clients, emphasizing the interactive and collaborative relationship between clients and health care professionals. Similarly, an important aspect of self-management is client responsibility, which is particularly important in home-based rehabilitation [<xref ref-type="bibr" rid="ref18">18</xref>].</p>
        <p>However, for the effective application of DR, it is not only important to identify digital technologies and their potential applications that can be integrated into home-based rehabilitation but also essential to equip health care professionals with the skills needed to provide high-quality rehabilitation, conferring them with the potential to develop the field multi-professionally.</p>
        <p>The COVID-19 pandemic has exacerbated the challenges faced by individuals in need of rehabilitation [<xref ref-type="bibr" rid="ref19">19</xref>]. In addition, there has been increased pressure on higher education institutions and health care professionals to develop DR practices that meet the needs of target populations [<xref ref-type="bibr" rid="ref20">20</xref>].</p>
        <p>To develop and implement DR solutions that meet client needs and ease the growing pressure on the health care system, it is necessary to provide a broad overview of existing, relevant, and future solutions shaping the constantly evolving market of technologies for home-based DR.</p>
      </sec>
      <sec>
        <title>Objective</title>
        <p>The scoping review aimed to identify digital technologies for home-based rehabilitation, predict new and emerging trends in DR, and report the influences of the COVID-19 pandemic on DR.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Overview</title>
        <p>The scoping review was performed based on an adapted framework described by Arksey and O’Malley [<xref ref-type="bibr" rid="ref21">21</xref>] by adding the improvements proposed by Levac et al [<xref ref-type="bibr" rid="ref22">22</xref>]. This framework includes 5 phases: identifying research questions, determining relevant studies, selecting studies, charting data, and consulting with key stakeholders and experts. The scoping review was reported consistent to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews; <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>). A protocol of this scoping review does not exist.</p>
      </sec>
      <sec>
        <title>Identification of Research Questions</title>
        <p>As the first step, the following research questions were identified:</p>
        <list list-type="bullet">
          <list-item>
            <p>Research question 1: What are the types of existing new or emerging digital technologies in home-based rehabilitation?</p>
          </list-item>
          <list-item>
            <p>Research question 2: Which trends can be identified for the home-based DR technologies and what are their advantages and disadvantages?</p>
          </list-item>
          <list-item>
            <p>Research question 3: How does the COVID-19 pandemic influence the development of DR?</p>
          </list-item>
        </list>
      </sec>
      <sec>
        <title>Identification of Relevant Studies</title>
        <p>To identify references related to the research questions, a scientific database search in PubMed, Embase, CINAHL, PsycINFO, and the Cochrane Library was performed in July 2021.</p>
        <p>The search strategy was first developed for PubMed and adapted to each database by using keywords; their synonyms; and related terms of “rehabilitation,” “home-based,” and “digital technologies.” These terms were connected with the Boolean operators “AND” and “OR” to obtain a wide spectrum of results from the various databases. The full search strategy for each database is presented in <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>. The search for relevant references was designed in 2 phases. The first phase involved searching references published from January 2015 to July 21, 2021. In the second phase, an additional search was performed in January 2022 to retrieve recent publications.</p>
        <p>To complement the findings regarding the trends of home-based DR, as well as the impact of the pandemic, gray literature sources were searched for unpublished materials in the native languages by the member institutes of the project “Competences for the new era of user-driven Digital Rehabilitation (DIRENE)” (Greek, Spanish, Finnish, German, and English). The gray literature was searched using Google, Google Scholar, Yahoo, OpenGrey, specific websites from each country’s government, thesis repositories, and university library websites that offer a comprehensive list of gray literature databases.</p>
      </sec>
      <sec>
        <title>Study Selection</title>
        <p>Study selection was performed using the web-based software, Covidence (version 2021; Veritas Health Innovation) [<xref ref-type="bibr" rid="ref23">23</xref>]. After a training period, 7 independent researchers from the DIRENE consortium performed study selection based on the eligibility criteria presented in <xref ref-type="boxed-text" rid="box1">Textbox 1</xref>. For every reference, 2 randomized researchers individually assessed the reference in terms of inclusion or exclusion. In cases of disagreement, a third researcher was included to resolve conflicts.</p>
        <boxed-text id="box1" position="float">
          <title>Eligibility criteria for study selection.</title>
          <p>
            <bold>Inclusion</bold>
          </p>
          <p>Article type</p>
          <list list-type="bullet">
            <list-item>
              <p>Every article type that is existing as a full text</p>
            </list-item>
          </list>
          <p>Language</p>
          <list list-type="bullet">
            <list-item>
              <p>English</p>
            </list-item>
          </list>
          <p>Publishing date</p>
          <list list-type="bullet">
            <list-item>
              <p>First phase: references published since January 1, 2015</p>
            </list-item>
            <list-item>
              <p>Second phase: references published since July 21, 2021</p>
            </list-item>
          </list>
          <p>Technology</p>
          <list list-type="bullet">
            <list-item>
              <p>Digital technology directly related to home-based rehabilitation</p>
            </list-item>
            <list-item>
              <p>Fully developed devices, applications, software, or prototypes and ideas</p>
            </list-item>
          </list>
          <p>Intervention</p>
          <list list-type="bullet">
            <list-item>
              <p>Every intervention in which a digital technology was used</p>
            </list-item>
          </list>
          <p>
            <bold>Exclusion</bold>
          </p>
          <p>Article type</p>
          <list list-type="bullet">
            <list-item>
              <p>Articles that were not available as full texts via common publishers, universities databases or directly requested from the publishing authors</p>
            </list-item>
          </list>
          <p>Language</p>
          <list list-type="bullet">
            <list-item>
              <p>Other languages than English</p>
            </list-item>
          </list>
          <p>Publishing date</p>
          <list list-type="bullet">
            <list-item>
              <p>First phase: references published before January 1, 2015</p>
            </list-item>
            <list-item>
              <p>Second phase: references published before July 21, 2021</p>
            </list-item>
          </list>
          <p>Technology</p>
          <list list-type="bullet">
            <list-item>
              <p>Nondigital technologies</p>
            </list-item>
            <list-item>
              <p>Technologies used after invasive procedures (eg, surgery to implant a device)</p>
            </list-item>
          </list>
          <p>Intervention</p>
          <list list-type="bullet">
            <list-item>
              <p>Intervention via telephone as a stand-alone intervention</p>
            </list-item>
            <list-item>
              <p>Intervention in a laboratory setting</p>
            </list-item>
          </list>
        </boxed-text>
      </sec>
      <sec>
        <title>Data Extraction and Data Charting</title>
        <p>A bibliometric analysis was performed as the first overview of the included publications. The software Zotero (version 6.0.10; Roy Rosenzweig Center for History and New Media, George Mason University) [<xref ref-type="bibr" rid="ref24">24</xref>] was used to indicate the number of publications per year and the journals of the included references.</p>
        <p>To identify new and emerging technologies for home-based rehabilitation, a co-occurrence analysis was performed. The software VOSviewer (version 1.6.18; Leiden University) [<xref ref-type="bibr" rid="ref25">25</xref>] was used for the analysis. The co-occurrence analysis was intended to map the results of the included publications, categorize the technologies mentioned in the publications, and provide a visualization of the output [<xref ref-type="bibr" rid="ref26">26</xref>]. For this purpose, a Research Information Systems (RIS) file of all included publications was uploaded to the program, and a text-based analysis was performed using a binary counting method of the most frequently occurring keywords [<xref ref-type="bibr" rid="ref26">26</xref>]. On the basis of the relevance score, the program automatically selected the most applicable keywords for the final analysis.</p>
        <p>Furthermore, a full-text analysis of all included reviews was conducted to filter the trends for home-based DR technologies and to present its advantages and disadvantages. The analysis aimed to extract relevant information about the technologies in terms of the goal, specification and application, population, and advantages and disadvantages of the technologies.</p>
        <p>The data of the gray literature search were analyzed to complement the results of the review analysis and to determine the influence of the COVID-19 pandemic on the development of DR. Each participating institution used an extraction sheet to obtain the information with respect to the research questions. All data were then summarized according to the following categories: type, aim, description of the technology, target population, and statements regarding the influence of the COVID-19 pandemic.</p>
      </sec>
      <sec>
        <title>Stakeholder Consultation</title>
        <p>The aim of the stakeholder consultation was to complement the results regarding the trends of digital technologies and the impact of the pandemic on DR from different perspectives. Therefore, a meeting with key stakeholders and experts was organized by 4 of the 5 collaborating universities of the DIRENE consortium (Greece, Finland, Austria, and Germany). Participants included clients with experience or specific interest in using digital technologies at home (10/56, 18%); rehabilitation professionals (13/56, 23%); experts from companies for future trends in health care (9/56, 16%); experts in digitalization (11/56, 20%); and representatives of public health administrations (6/56, 11%), social and welfare departments (4/56, 7%), and national platforms for digitalization in rehabilitation (3/56, 5%).</p>
        <p>The meetings consisted of a short introduction to the project and the presentation of the preliminary results of the review. Stakeholders shared their views on the identified trends in digital technologies used in rehabilitation. They discussed the potential synthesis of technologies in home-based rehabilitation and examined factors influencing DR. All the information was summarized in a final standardized report by each participating institution. The results were then analyzed in line with the Framework Approach [<xref ref-type="bibr" rid="ref27">27</xref>]. On the basis of the research questions, a deductive approach was used to form the key themes and subthemes. After reviewing the results of the stakeholder consultation for each participating institution, the subthemes were adjusted inductively. Subsequently, the results of each stakeholder consultation were coded. Each code in a report was then summarized, abstracted, and tabulated for each subtheme. Then, the statements of all stakeholder consultations were summarized per key theme.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <p>The process of paper selection for each research question is shown in <xref rid="figure1" ref-type="fig">Figure 1</xref>.</p>
      <fig id="figure1" position="float">
        <label>Figure 1</label>
        <caption>
          <p>Flowchart of the paper-selection process. RQ: research question.</p>
        </caption>
        <graphic xlink:href="rehab_v10i1e43615_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
      </fig>
      <sec>
        <title>Research Question 1: New or Emerging Digital Technologies in Home-Based Rehabilitation</title>
        <p>Bibliometric and co-occurrence analyses were performed to provide an overview of the included references and identify new or emerging technologies in home-based rehabilitation. For these analyses, 2437 records were included.</p>
        <p>All 2437 included records for the bibliometric and co-occurrence analyses were published between January 2015 and January 2022. Over the past years, the number of publications has steadily increased annually, from 211 (8.66%) in 2015 to 544 (22.32%) in 2021. In addition, most research papers were published in 2021 (n=544, 22.32%).</p>
        <p>In total, 53 keywords with a frequency of ≥10 were selected from 59,718 keywords, and a co-occurrence analysis was performed, as shown in <xref rid="figure2" ref-type="fig">Figure 2</xref>.</p>
        <fig id="figure2" position="float">
          <label>Figure 2</label>
          <caption>
            <p>VOSviewer co-occurrence analysis of the most mentioned keywords referring to home-based rehabilitation. Map generated in VOSviewer version 1.6.18; Leiden University.</p>
          </caption>
          <graphic xlink:href="rehab_v10i1e43615_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <p>As presented in <xref rid="figure2" ref-type="fig">Figure 2</xref>, the research themes of home-based DR can be divided into 6 clusters: sensors (blue), robotics (purple), gamification (green), virtual reality (VR) and augmented reality (AR; turquoise), mobile apps (red), and digital platforms (yellow). Each node represents a keyword. The size of the node indicates the number of occurrences of that keyword, and the link connecting the 2 nodes indicates that a keyword appears in common with another keyword. The thickness of the connection line indicates the strength of co-occurrence between the 2 keywords. The visualization indicates that the keyword “sensor” is the most frequently occurring term throughout the included publications compared with other keywords represented in this cluster.</p>
        <p>Further analysis of keywords that occurred ≥10 times provided an overview of the mentioned populations in which the identified technologies were used in home-based rehabilitation, as shown in <xref ref-type="table" rid="table1">Table 1</xref>.</p>
        <p>It can be seen that the cumulative sum of stroke and related synonyms are the most occurring conditions related to home-based rehabilitation among the publications. Chronic obstructive pulmonary disease (COPD) and its synonyms ranked second. The third most common disease mentioned in the included publications is multiple sclerosis (MS).</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Population or symptoms groups sorted per occurrence in the bibliometric analysis.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="700"/>
            <col width="300"/>
            <thead>
              <tr valign="top">
                <td>Population</td>
                <td>Occurrences, n</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Stroke patient</td>
                <td>100</td>
              </tr>
              <tr valign="top">
                <td>Chronic stroke</td>
                <td>38</td>
              </tr>
              <tr valign="top">
                <td>Chronic stroke patient</td>
                <td>29</td>
              </tr>
              <tr valign="top">
                <td>Chronic stroke survivor</td>
                <td>21</td>
              </tr>
              <tr valign="top">
                <td>Poststroke patient</td>
                <td>15</td>
              </tr>
              <tr valign="top">
                <td>COPD<sup>a</sup></td>
                <td>102</td>
              </tr>
              <tr valign="top">
                <td>Chronic obstructive pulmonary disease</td>
                <td>77</td>
              </tr>
              <tr valign="top">
                <td>Severe COPD</td>
                <td>13</td>
              </tr>
              <tr valign="top">
                <td>MS<sup>b</sup></td>
                <td>116</td>
              </tr>
              <tr valign="top">
                <td>MS patient</td>
                <td>17</td>
              </tr>
              <tr valign="top">
                <td>Parkinson</td>
                <td>98</td>
              </tr>
              <tr valign="top">
                <td>Parkinson disease</td>
                <td>13</td>
              </tr>
              <tr valign="top">
                <td>Spinal cord injury</td>
                <td>61</td>
              </tr>
              <tr valign="top">
                <td>Traumatic brain injury</td>
                <td>48</td>
              </tr>
              <tr valign="top">
                <td>Aphasia<sup>c</sup></td>
                <td>30</td>
              </tr>
              <tr valign="top">
                <td>Hemiplegia<sup>c</sup></td>
                <td>16</td>
              </tr>
              <tr valign="top">
                <td>Cardiovascular disease</td>
                <td>55</td>
              </tr>
              <tr valign="top">
                <td>Heart failure</td>
                <td>55</td>
              </tr>
              <tr valign="top">
                <td>Myocardial infarction</td>
                <td>26</td>
              </tr>
              <tr valign="top">
                <td>Coronary heart disease</td>
                <td>23</td>
              </tr>
              <tr valign="top">
                <td>Hypertension<sup>c</sup></td>
                <td>22</td>
              </tr>
              <tr valign="top">
                <td>Acute coronary syndrome</td>
                <td>19</td>
              </tr>
              <tr valign="top">
                <td>Chronic heart failure</td>
                <td>18</td>
              </tr>
              <tr valign="top">
                <td>Ischemic heart disease</td>
                <td>17</td>
              </tr>
              <tr valign="top">
                <td>Coronavirus disease</td>
                <td>57</td>
              </tr>
              <tr valign="top">
                <td>Chronic respiratory disease</td>
                <td>12</td>
              </tr>
              <tr valign="top">
                <td>Dyspnoea<sup>c</sup></td>
                <td>14</td>
              </tr>
              <tr valign="top">
                <td>Knee osteoarthritis</td>
                <td>30</td>
              </tr>
              <tr valign="top">
                <td>Osteoarthritis</td>
                <td>25</td>
              </tr>
              <tr valign="top">
                <td>Hip fracture</td>
                <td>21</td>
              </tr>
              <tr valign="top">
                <td>Chronic low back pain</td>
                <td>17</td>
              </tr>
              <tr valign="top">
                <td>Knee injury<sup>c</sup></td>
                <td>13</td>
              </tr>
              <tr valign="top">
                <td>Total hip arthroplasty</td>
                <td>13</td>
              </tr>
              <tr valign="top">
                <td>Total knee arthroplasty</td>
                <td>12</td>
              </tr>
              <tr valign="top">
                <td>Depressive symptom<sup>c</sup></td>
                <td>32</td>
              </tr>
              <tr valign="top">
                <td>Breast cancer</td>
                <td>16</td>
              </tr>
              <tr valign="top">
                <td>Diabetes</td>
                <td>16</td>
              </tr>
              <tr valign="top">
                <td>Alzheimer</td>
                <td>17</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table1fn1">
              <p><sup>a</sup>COPD: chronic obstructive pulmonary disease.</p>
            </fn>
            <fn id="table1fn2">
              <p><sup>b</sup>MS: multiple sclerosis.</p>
            </fn>
            <fn id="table1fn3">
              <p><sup>c</sup>The given groups represent symptoms that occurred in the bibliometric analysis.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Research Question 2: Trends in Home-Based DR and its Advantages and Disadvantages</title>
        <sec>
          <title>Overview</title>
          <p>To identify the trends for home-based DR technologies and display their advantages and disadvantages, 95 reviews (systematic reviews: n=51, 54%; reviews: n=44, 46%) were included (<xref rid="figure1" ref-type="fig">Figure 1</xref>) in the review analysis. For the technologies “brain-computer interface” and “machine learning,” no reviews could be found. However, the co-occurrence analysis showed results for these 2 technologies (<xref rid="figure2" ref-type="fig">Figure 2</xref>). All references were screened again these topics. Therefore, 22 articles were additionally considered for the analysis.</p>
          <p>It is essential to note that each publication addressed one or more types of technologies that are often used in combination with another. For example, exergames or serious games that are used with a head-mounted display are grouped in the category “virtual/augmented reality,” and the games in which a client plays in a virtual environment without using technology for an immersive experience are categorized as “gamification.” Likewise, the technology was not named in either category to avoid duplication.</p>
          <p>To provide a definition for each identified technology, the DIRENE consortium developed definitions based on the current literature using a Delphi process until a consensus was reached [<xref ref-type="bibr" rid="ref28">28</xref>] (<xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref> [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref29">29</xref>-<xref ref-type="bibr" rid="ref46">46</xref>]).</p>
          <p><xref ref-type="table" rid="table2">Table 2</xref> provides an overview of the identified technologies for home-based DR and shows their advantages and disadvantages.</p>
          <table-wrap position="float" id="table2">
            <label>Table 2</label>
            <caption>
              <p>Summary of the identified technologies discussed in home-based rehabilitation ordered by the specification of technology, specification of application, advantages, and disadvantages or limitations.</p>
            </caption>
            <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
              <col width="30"/>
              <col width="100"/>
              <col width="260"/>
              <col width="0"/>
              <col width="220"/>
              <col width="310"/>
              <col width="0"/>
              <col width="80"/>
              <thead>
                <tr valign="top">
                  <td colspan="2">Category of technologies and specification of technologies</td>
                  <td colspan="2">Specification of application</td>
                  <td>Advantage</td>
                  <td colspan="2">Disadvantage or limitation</td>
                  <td>Included reviews or articles</td>
                </tr>
              </thead>
              <tbody>
                <tr valign="top">
                  <td colspan="8">
                    <bold>Sensors</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Inertial sensors</td>
                  <td>Measuring, assessing, capturing, and tracking movement, motor activity, gait analysis, falls, blood flow, and respiratory rate; movement coding for control keyboards and displays; control and implementation of tasks and human-machine interfaces such as wheelchairs, smart shoes, and robots; and gesture recognition to aid communication between people with hearing impairments and listeners</td>
                  <td colspan="2">Relatively inexpensive, portable, and user-friendly; provide sufficiently accurate and fast movement data for rehabilitation analysis and evaluation; simple principles of operation</td>
                  <td>Loss of accuracy due to factors such as position of sensor placement, reliability of skin attachment, or an interaction effect with the sensors</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref47">47</xref>-<xref ref-type="bibr" rid="ref49">49</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>IMUs<sup>a</sup></td>
                  <td>Measuring, assessing, capturing, or tracking movement and posture; predicting falls; and providing biofeedback</td>
                  <td colspan="2">Small design, low cost, simple handling, capable of delivering accurate and valid analysis, and captures 3-dimensional linear accelerations from accelerometers and angular velocities from gyroscope. Combination of linear and rotational data enables a more complete picture of motion, as it has many <italic>df</italic></td>
                  <td>Lack of validation in terms of capturing posture and motion and providing biofeedback. To measure accurately, at least 3 sensors are necessary. Multiple sensors require connection via wires and attachment to the body, often by strapping, and they may be challenging to remove and reattach</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref50">50</xref>- <xref ref-type="bibr" rid="ref54">54</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Accelerometer</td>
                  <td>Measuring, assessing, capturing, and monitoring movement, motor activity, physical activity, posture, respiratory rate, steps, falls, sleep, and gait analysis and providing biofeedback</td>
                  <td colspan="2">Capture linear acceleration data in 1-3 planes of motion, can be used when magnetic interference is a concern, uses the gravity vector as a reference, can be easily attached to clients at low cost, and simple principles of operation</td>
                  <td>Sparse data-collection, often multiple sensors required</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref49">49</xref>, <xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref53">53</xref>, <xref ref-type="bibr" rid="ref55">55</xref>-<xref ref-type="bibr" rid="ref57">57</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Gyroscope</td>
                  <td>Measuring, assessing, and capturing movement and motor activity</td>
                  <td colspan="2">Can be easily attached to clients</td>
                  <td>Have no reference as gravity and are therefore unable to establish an initial state, leading to error accumulation</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref56">56</xref>, <xref ref-type="bibr" rid="ref57">57</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Infrared sensors</td>
                  <td>Measuring, assessing, capturing, and monitoring motor activity and posture</td>
                  <td colspan="2">User-friendly</td>
                  <td>No data could be extracted from the included literature</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref58">58</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Flex sensors</td>
                  <td>Control and implementation of tasks and human-machine interfaces such as wheelchairs, smart shoes, and robots; and gesture recognition to aid communication between deaf people and listeners</td>
                  <td colspan="2">No data extracted from included literature</td>
                  <td>No data extracted from included literature</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref51">51</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>GPS and smartwatch</td>
                  <td>Measuring and monitoring steps and physical activity</td>
                  <td colspan="2">No data extracted from included literature</td>
                  <td>No data extracted from included literature</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref59">59</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Photo sensors</td>
                  <td>Measuring temperature, respiratory rate, and emotion recognition</td>
                  <td colspan="2">User-friendly</td>
                  <td>No data extracted from included literature</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>(Vision) cameras</td>
                  <td>Measuring, assessing, and capturing movement, heart and respiratory rate, gait analysis, and blood flow; control and implementation of tasks and human-machine interfaces such as wheelchairs, smart shoes, or robots, and emotion recognition</td>
                  <td colspan="2">Available commercially and at low costs</td>
                  <td>When measuring motion, vision cameras without an optical motion–tracking system provide 2D information about the captured scene; lack of the third dimension’s information imposes limits on the evaluation accuracy</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref48">48</xref>, <xref ref-type="bibr" rid="ref56">56</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>EMG<sup>b</sup></td>
                  <td>Measuring heart rate, gait analysis, movement coding for control keyboards and displays; gesture recognition to aid communication between deaf people and listeners; and recognition of fascial expressions</td>
                  <td colspan="2">Available commercially and at low costs</td>
                  <td>To measure bioelectric signals, often inertial sensors have to be added</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref50">50</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Microphone</td>
                  <td>Measuring and tracking social activity</td>
                  <td colspan="2">Available commercially and at low costs</td>
                  <td>No data extracted from included literature</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Electrodes</td>
                  <td>Prevention of dementia, treatment for behavioral change, activating muscle contraction, and biofeedback</td>
                  <td colspan="2">No data extracted from included literature</td>
                  <td>Multiple sensors are often required</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref60">60</xref>, <xref ref-type="bibr" rid="ref61">61</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Chemical and glucose sensors</td>
                  <td>Glucose monitoring</td>
                  <td colspan="2">No data extracted from included literature</td>
                  <td>Requires a regular calibration to reduce errors</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref47">47</xref>]</td>
                </tr>
                <tr valign="top">
                  <td colspan="8">
                    <bold>Robotics and brain-computer interface</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Robotic gloves</td>
                  <td>Measuring, assessing, capturing, and tracking motor function; supporting hands and finger movement; strengthening muscular activity and hand and finger coordination; and assisting ADLs<sup>c</sup></td>
                  <td colspan="2">Promotes engagement and motivation in therapy</td>
                  <td>Different operating characteristics, high costs, and predominantly passive in nature when used without a therapist</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref62">62</xref>-<xref ref-type="bibr" rid="ref64">64</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Exoskeleton for upper and lower limbs</td>
                  <td>Active, passive, and triggered assistance of movement; implementing movement; and gait training</td>
                  <td colspan="2">Promotes engagement and motivation in therapy, delivers high-intensity training compared with therapist-only training and assists or helps to perform movement even if the client cannot initiate movement</td>
                  <td>General: individual physical characteristics (cognitive, communication, visual problems, and motor impairments) may limit the use of exoskeletons; the need to be assisted by others to operate the rehabilitation robot at home; skills required to operate the system; high purchase and maintenance costs; and limited accessibility. Exoskeletons lower limbs: high risk of falls, there is a need to learn how to use the exoskeleton while walking, and there are special adaptation requirements when using the device</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref63">63</xref>- <xref ref-type="bibr" rid="ref67">67</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Robotic device for upper and lower limbs</td>
                  <td>Active and passive assistance, supporting movement, improving movement, and assisting gait</td>
                  <td colspan="2">Able to generate a wide variety of forces and motions and deliver measurable doses and intensities of therapy</td>
                  <td>Require large amounts of physical space and appropriate facilities such as tables and chairs for setup; some robots generate large forces, which can create theoretical safety concerns during unsupervised use at home</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref54">54</xref>, <xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref64">64</xref>- <xref ref-type="bibr" rid="ref66">66</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Brain-computer interface</td>
                  <td>Active and passive assistance of movement, implementing movement, supporting ADLs, and enable or support communication with environment</td>
                  <td colspan="2">Home use is possible and enables movement through brain activity</td>
                  <td>In its infancy, low usability rate, and often costly</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref68">68</xref>-<xref ref-type="bibr" rid="ref76">76</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Social robots</td>
                  <td>Supporting ADLs</td>
                  <td colspan="2">Could reduce loneliness, older individuals are willing to use robotic technologies</td>
                  <td>Acceptance rate in healthy participants is low</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref77">77</xref>]</td>
                </tr>
                <tr valign="top">
                  <td colspan="8">
                    <bold>Gamification</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Serious games</td>
                  <td>Improving balance; gait; mobility; postural control; motor, physical, and cognitive functioning; adherence; and self-management</td>
                  <td colspan="2">Promote engagement and motivation in therapy; specific exercises are provided based on clients’ aims. The training process is monitored, and the training plan is adapted accordingly</td>
                  <td>Additional hardware is costly, requires certain skills for client and the therapist to operate, health professional should monitor the compliance with the prescribed tasks at a regular basis to make adaptions to the rehabilitation plan, and diverse acceptance rate</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref78">78</xref>- <xref ref-type="bibr" rid="ref80">80</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Exergames</td>
                  <td>Improving balance; gait; mobility; postural control; and motor, physical, and cognitive function; preventing falls; and reducing symptoms of chronic respiratory diseases</td>
                  <td colspan="2">Commercially available, promote engagement and motivation in therapy, and many are low-cost systems</td>
                  <td>Specific guidance and tailored interventions to the clients’ needs is often lacking. Devices are not always designed for people with disabilities. Diverse adherence rate</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref54">54</xref>, <xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref81">81</xref>- <xref ref-type="bibr" rid="ref92">92</xref>]</td>
                </tr>
                <tr valign="top">
                  <td colspan="8">
                    <bold>Virtual and augmented reality</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Augmented reality</td>
                  <td>Improving physical functioning, range of motion, and gait</td>
                  <td colspan="2">Promotes engagement and motivation in therapy, no proof to cause symptoms of “simulator sickness”</td>
                  <td>In its infancy and requires further investigation with regard to their effectiveness. Dizziness may occur during use</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref93">93</xref>,<xref ref-type="bibr" rid="ref94">94</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Virtual reality</td>
                  <td>Improving physical functioning, fitness, balance, postural control, vestibular dysfunction, and anxiety</td>
                  <td colspan="2">Promotes engagement and motivation in therapy. Some systems are commercially available at low costs</td>
                  <td>Potential side effect known as “motion sickness” may occur during use. Fully immersive systems are not commercially available and not at low costs</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref93">93</xref>,<xref ref-type="bibr" rid="ref95">95</xref>- <xref ref-type="bibr" rid="ref99">99</xref>]</td>
                </tr>
                <tr valign="top">
                  <td colspan="8">
                    <bold>Digital and mobile apps</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>App</td>
                  <td>Measuring, assessing, capturing, and tracking rehabilitation process and health behavior, medication and rehabilitation adherence, and active and passive movement; providing and performing assessments; promoting self-management, physical activity, and healthy lifestyle; reducing falls; improving physical functioning, trunk control, dexterity, cognitive and language skills, and mobility; providing psychosocial support, coaching, secondary prevention; and obtaining support from other people</td>
                  <td colspan="2">Low cost, commercially available, provides access to some rehabilitation measure, beneficial to combine app solutions (eg, for diagnosis, intervention, or monitoring), increase engagement in therapy, and supports connection between health care professional and client through real-time transmission of health data</td>
                  <td>Accuracy of measuring ROM<sup>d</sup> is not tested or validated yet. Access and use can be different between countries due to cultural background, availability of high-speed connection, and trust in health care professionals. Correct use of digital technology may be affected by health condition itself (eg, motor disability, visual impairment, psychiatric comorbidities, cognitive dysfunction). Some of the apps could only be used in combination with another technology (eg, smartwatch). Some apps did not offer a platform to facilitate interaction with health professionals; some apps are outdated; some apps lack of disclosing sponsorship, authors’ affiliations, credentials, and sources or references of information; and some apps do not always cover all the rehabilitation needs for the client. Security aspects are not always considered</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref52">52</xref>, <xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref59">59</xref>, <xref ref-type="bibr" rid="ref100">100</xref>-<xref ref-type="bibr" rid="ref114">114</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Web-based program</td>
                  <td>Measuring, assessing, capturing, and tracking, rehabilitation process, health behavior, and medication and rehabilitation adherence; providing and performing assessments; promoting self-management, physical activity, and healthy lifestyle; improving physical functioning, balance, postural control, endurance, strength, and cognitive skills; obtaining support from other people</td>
                  <td colspan="2">Real-time feedback is possible, low cost, commercially available, access to some rehabilitation measures, beneficial to combine app solutions (eg, for diagnosis, intervention, or monitoring), engagement in therapy, supports connection between health care professional and client through real-time transmission of health data</td>
                  <td>Access and use can be different between countries due to cultural background, availability of high-speed connection, and trust in health care professionals; correct use of digital technology may be affected by health condition itself (eg, motor disability, visual impairment, psychiatric comorbidities, and cognitive dysfunction); sometimes unreliable connections</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref52">52</xref>, <xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref59">59</xref>, <xref ref-type="bibr" rid="ref100">100</xref>,<xref ref-type="bibr" rid="ref104">104</xref>, <xref ref-type="bibr" rid="ref107">107</xref>-<xref ref-type="bibr" rid="ref111">111</xref>, <xref ref-type="bibr" rid="ref113">113</xref>,<xref ref-type="bibr" rid="ref115">115</xref>- <xref ref-type="bibr" rid="ref122">122</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Videoconference</td>
                  <td>Promoting self-management and healthy lifestyle, improving mobility and physical functioning, monitoring rehabilitation process and exercises, and obtaining support from other people</td>
                  <td colspan="2">Remote rehabilitation and real-time feedback possible, supports motivation in rehabilitation, low cost, commercially available, possibility to reduce duration of inpatient hospitalization, may reduce costs</td>
                  <td>Workability is not always practical, lack of physical interaction between clients and therapists, technical skills are necessary for the use of some services. Main policy challenges related to home-based telerehabilitation are not yet fully resolved (eg, costs, reimbursement, data protection, liability, and system security). Access and use can be different between countries due to cultural background, availability of high-speed connection, and trust in health care professionals. Correct use of digital technology may be affected by health condition itself (eg, motor disability, visual impairment, psychiatric comorbidities, and cognitive dysfunction)</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref52">52</xref>, <xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref59">59</xref>, <xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref103">103</xref>, <xref ref-type="bibr" rid="ref104">104</xref>,<xref ref-type="bibr" rid="ref113">113</xref>]</td>
                </tr>
                <tr valign="top">
                  <td colspan="8">
                    <bold>Internet of Things</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Smart homes and ambient-assisted living</td>
                  <td>Detecting and preventing mild cognitive impairments and dementia, improving cognitive functioning, supporting tasks of daily living, and monitoring health status</td>
                  <td colspan="2">Monitoring clients’ health status in their natural environment</td>
                  <td>Use of the technology is complex for clients with disabilities. Technology could be expensive—costs for installation, repair and maintenance occur, ethical considerations. Privacy concerns and clients’ safety are often discussed issues</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref58">58</xref>, <xref ref-type="bibr" rid="ref101">101</xref>,<xref ref-type="bibr" rid="ref115">115</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Living labs</td>
                  <td>Assessing motor performance</td>
                  <td colspan="2">Testing is possible in the home environment, records sufficient objective measures, and variable test administration by clients is bypassed</td>
                  <td>Clients may not be fully informed about the possibilities and limitations of the technologies or are not cognitively able to understand their implications; too many data are collected, most important information has to be filtered, may violate client privacy, and challenging to comply with ethical and data protection guidelines. Sometimes additional technologies have to be attached to clients such as electrodes; this can be demanding and uncomfortable (eg, constant use and attachment or detachment of electrodes)</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref115">115</xref>,<xref ref-type="bibr" rid="ref123">123</xref>]</td>
                </tr>
                <tr valign="top">
                  <td colspan="8">
                    <bold>AI<sup>d</sup> and machine learning</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>AI and machine learning</td>
                  <td>Providing individualized therapy, trainings plan, motion feedback in real time, and classification of movement</td>
                  <td colspan="2">Have the potential to predict adherence and client conditions</td>
                  <td>In its infancy; some decisions could be taken over from AI and machine learning algorithms; and acceptable model accuracy can be reached after using the technology multiple times</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref124">124</xref>-<xref ref-type="bibr" rid="ref136">136</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Chatbots and conversational agents</td>
                  <td>Organizing rehabilitation process, treatment of mental disorders, and assisted living</td>
                  <td colspan="2">Rehabilitation management is supported, entertaining tool for rehabilitation, low cost, and no stigmatization in mental disorder treatment</td>
                  <td>In its infancy, more research is needed; most conversational agents are not commercially available; some individuals may become overly attached, some chatbots give inappropriate responses related to the health problem; there are no laws and regulations for the use of chatbots, and the legal responsibility for adverse events related to chatbots has not yet been clarified</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref121">121</xref>,<xref ref-type="bibr" rid="ref137">137</xref>- <xref ref-type="bibr" rid="ref139">139</xref>]</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Virtual humans</td>
                  <td>Secondary prevention, promoting physical activity, and treatment of mental illness</td>
                  <td colspan="2">Appear natural for human-machine interaction and give the illusion of liveliness of interaction with a real person, exude trustworthiness and credibility</td>
                  <td>There is the fear of replacing a health care professional, which can lead to considerable disadvantages</td>
                  <td colspan="2">[<xref ref-type="bibr" rid="ref121">121</xref>]</td>
                </tr>
              </tbody>
            </table>
            <table-wrap-foot>
              <fn id="table2fn1">
                <p><sup>a</sup>IMU: inertial measurement unit.</p>
              </fn>
              <fn id="table2fn2">
                <p><sup>b</sup>EMG: electromyography.</p>
              </fn>
              <fn id="table2fn3">
                <p><sup>c</sup>ADL: activity of daily living.</p>
              </fn>
              <fn id="table2fn4">
                <p><sup>d</sup>AI: artificial intelligence.</p>
              </fn>
            </table-wrap-foot>
          </table-wrap>
        </sec>
        <sec>
          <title>Sensors</title>
          <p>In 14 reviews, sensors were used as an assessment and diagnostic tool, as an intervention, as support for daily living, and as a monitoring solution. Sensors were the most used technology in the included reviews and were often used in combination with other technologies (<xref rid="figure2" ref-type="fig">Figure 2</xref>).</p>
          <p>Thirteen groups of sensors could be identified for use in rehabilitation. The groups can be divided into 4 subgroups depending on their purpose: motion-capturing sensors (motor activity [<xref ref-type="bibr" rid="ref51">51</xref>], posture [<xref ref-type="bibr" rid="ref53">53</xref>], falls [<xref ref-type="bibr" rid="ref140">140</xref>], and gait [<xref ref-type="bibr" rid="ref141">141</xref>]); vital parameter sensors (heart rate [<xref ref-type="bibr" rid="ref142">142</xref>], pulse, respiratory rate [<xref ref-type="bibr" rid="ref143">143</xref>], blood oxygen [<xref ref-type="bibr" rid="ref144">144</xref>], glucose [<xref ref-type="bibr" rid="ref145">145</xref>], and skin and body temperature [<xref ref-type="bibr" rid="ref146">146</xref>]); activity-tracking sensors (steps [<xref ref-type="bibr" rid="ref147">147</xref>] and physical activity [<xref ref-type="bibr" rid="ref148">148</xref>]); and sensors intended to capture behavior (sleep [<xref ref-type="bibr" rid="ref149">149</xref>] and social behaviors [<xref ref-type="bibr" rid="ref150">150</xref>]).</p>
          <p>Sensors are embedded in wearables that are worn as normal clothes or in footwear (eg, insole pressure sensors [<xref ref-type="bibr" rid="ref151">151</xref>]); cameras; accessories (eg, smartwatches [<xref ref-type="bibr" rid="ref152">152</xref>], bracelets [<xref ref-type="bibr" rid="ref148">148</xref>], rings, chest belts, and glasses [<xref ref-type="bibr" rid="ref131">131</xref>]); or smartphones, or they can be directly attached to the skin (eg, electrodes [<xref ref-type="bibr" rid="ref61">61</xref>]).</p>
          <p>Inertial measurement units (IMUs) are the combination of inertial sensors, namely, the combination of one or more accelerometers, one or more gyroscopes, and, potentially, one or more magnetometers, to measure the force, angular rate, and orientation of the body [<xref ref-type="bibr" rid="ref53">53</xref>]. These IMUs are designed to capture physical movement and posture in a markerless fashion, with the intention of detecting dysfunctions, motor impairments, activity limitations, and unhealthy conditions [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref52">52</xref>-<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref153">153</xref>].</p>
          <p>Given the existence of IoT, sensors can collect data and transfer them to other devices to visualize the output and thus provide biofeedback to the client. Biofeedback systems consist of an input sensor, a data-processing system, and an output device that displays the feedback [<xref ref-type="bibr" rid="ref50">50</xref>]. The output can be provided through the visualization displayed on a screen, auditory feedback via voice outputs, or vibrotactile feedback of the input sensor. For example, robotic gloves can be used as sensor gloves equipped with flex sensors and vibrotactile motors that provide vibrotactile feedback through the motors at the fingertips. Sometimes, biofeedback systems are embedded in games for rehabilitation purposes in which the client must playfully perform movement tasks that are displayed on a screen. Biofeedback can improve outcomes by engaging clients and has the potential to support clients in targeted exercises during home-based rehabilitation [<xref ref-type="bibr" rid="ref50">50</xref>].</p>
          <p>It is useful to apply vital parameter sensors to monitor the health status of clients during rehabilitation. Kwon et al [<xref ref-type="bibr" rid="ref144">144</xref>] developed an app for clients with COPD and monitored their heart rates and blood oxygen saturation via sensors embedded in smartphones. An alarm function alerts the client regarding any critical health status during physical activity, such as when the values (S<sub>P</sub>O<sub>2</sub> and heart rate) fall below certain thresholds. Thus, the client has the opportunity for self-monitoring, that is, to receive feedback on the correlation between physical activity and body reactions to adjust such behavior as needed. Health care professionals can also estimate these data using a dashboard where the data are collected. After 6 weeks, the application led to a significant reduction in symptoms associated with COPD compared with the control group. The intervention group’s self-assessment of the impact of the disease also improved significantly.</p>
          <p>Overall, stakeholders emphasized the importance of sensors in DR.</p>
        </sec>
        <sec>
          <title>Robotics and Brain-Computer Interfaces</title>
          <p>In total, 9 reviews investigated the use and effects of robots in rehabilitation. Furthermore, 9 articles that explained the use of brain-computer interfaces (BCIs) in rehabilitation were included.</p>
          <p>Robotic gloves [<xref ref-type="bibr" rid="ref154">154</xref>] are categorized as rehabilitation robots, and they are machines with sensors and actuators [<xref ref-type="bibr" rid="ref40">40</xref>]. There are several types of robotic gloves [<xref ref-type="bibr" rid="ref154">154</xref>]. For example, soft robotic gloves are used in upper-limb rehabilitation for clients with neurological conditions, such as stroke and spinal cord injury. These are used to assist, replace, or promote the movement of fingers, hands, and wrists and to facilitate activities of daily living (ADLs) [<xref ref-type="bibr" rid="ref155">155</xref>]. They can also be used for motion capture to assess arm function and movement control [<xref ref-type="bibr" rid="ref156">156</xref>]. Robotic gloves have the potential to be easily used by someone who is at home alone.</p>
          <p>Exoskeletons are wearable robotic units controlled by computer boards [<xref ref-type="bibr" rid="ref157">157</xref>,<xref ref-type="bibr" rid="ref158">158</xref>]. A distinction is made between “rigid” and “soft” exoskeletons. Because of the perspective of home-based rehabilitation in this review, only soft exoskeletons were used in the identified references. Exoskeletons can be applied to the upper or lower limbs in home-based rehabilitation to assist clients and help perform passive movements in clients with neurological diseases such as stroke, spinal cord injuries, and cerebral palsy [<xref ref-type="bibr" rid="ref159">159</xref>]. Furthermore, these devices can assist in the ADLs.</p>
          <p>The application of noninvasive BCIs has changed over the last decade. This change allows health care professionals to offer this treatment in a home-based setting, although this approach remains under development. In the past, the application of BCI technologies in a home environment was hampered by the fact that the operation of these systems required the supervision of an expert. In a home-based setting, BCI technologies are used for people with severe motor impairments, such as those who have experienced a stroke, traumatic brain injury, spinal cord injury, or locked-in syndrome. These technologies can help such clients to enable or support communication with their environment or performing daily tasks.</p>
          <p>BCI-based applications can be used to control daily aids such as wheelchairs, prosthetics, video games, and various computer applications [<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref75">75</xref>]. Yang et al [<xref ref-type="bibr" rid="ref75">75</xref>] proposed a system that helps physically disordered people to control external devices using gazing and eye blinks. It offers the opportunity to conduct routine daily tasks using brain signals directly, without any physical movement.</p>
          <p>Zulauf-Czaja et al [<xref ref-type="bibr" rid="ref76">76</xref>] developed a system for hand rehabilitation based on a BCI interface that uses an electroencephalographic device combined with functional electrical stimulation. The hand therapy consisted of the attempted movement of one hand to lower the power of the sensory-motor electroencephalography and thereby activate the functional electrical stimulation, which causes flexion and extension of the wrist.</p>
          <p>Stakeholders saw high potential in the use of exoskeletons in rehabilitation if the devices are able to make their own adjustments in terms of speed and level of assistance based on data collected from the client. Furthermore, stakeholders indicated rehabilitation robots’ low accessibility to clients, as these are mostly available at research level. The stakeholders also emphasized the possibility of the combined use of robotic devices with gamification to encourage clients’ motivation during the rehabilitation process due to gaming elements or appealing environments.</p>
        </sec>
        <sec>
          <title>Gamification</title>
          <p>In 19 reviews, games were used either specifically for rehabilitation (serious games: n=4, 21%) or commercial use (exergames: n=15, 79%).</p>
          <p>Gamification was mostly used as an intervention in neurological rehabilitation to improve physical function, balance, gait [<xref ref-type="bibr" rid="ref84">84</xref>,<xref ref-type="bibr" rid="ref90">90</xref>], and motor function [<xref ref-type="bibr" rid="ref89">89</xref>,<xref ref-type="bibr" rid="ref92">92</xref>]. One review applied gaming elements in rehabilitation to improve cognitive function in patients with neurological disorders (stroke, MS, and cognitive impairment) [<xref ref-type="bibr" rid="ref91">91</xref>]. Mura et al [<xref ref-type="bibr" rid="ref91">91</xref>] stated that no conclusion can be drawn regarding the effectiveness of exergames in improving the cognitive function in persons with neurological disabilities. The small sample sizes of the selected studies, dissimilarity in outcomes and assessments used to measure the cognitive function, and heterogeneity of populations included in the analysis restricted the explanatory power of the review.</p>
          <p>In a number of reviews [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref78">78</xref>-<xref ref-type="bibr" rid="ref80">80</xref>] in which serious games were described, hardware such as robotic devices and gloves and leap motion sensors were used as supplements to the game.</p>
          <p>Publications deployed exergames using commercial hardware, such as the PlayStation, Nintendo Wii, Xbox Kinect, and associated elements such as the Wii balance board and games for these consoles [<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref83">83</xref>,<xref ref-type="bibr" rid="ref84">84</xref>,<xref ref-type="bibr" rid="ref88">88</xref>-<xref ref-type="bibr" rid="ref90">90</xref>,<xref ref-type="bibr" rid="ref92">92</xref>,<xref ref-type="bibr" rid="ref160">160</xref>]. Biomarkers such as leap motion sensors and Microsoft Kinect are used in motion capturing and creating physical images on the screen.</p>
          <p>Overall, a low strength of evidence has been shown until now regarding exergames and serious games in improving physical functioning. This is due to a lack of long-term randomized controlled trials (RCTs) with homogeneous population and large sample sizes and specific outcome measures [<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref82">82</xref>,<xref ref-type="bibr" rid="ref84">84</xref>,<xref ref-type="bibr" rid="ref88">88</xref>,<xref ref-type="bibr" rid="ref89">89</xref>,<xref ref-type="bibr" rid="ref91">91</xref>,<xref ref-type="bibr" rid="ref92">92</xref>]. Stakeholders also stated that the long-term effects of gamification are yet to be proven.</p>
        </sec>
        <sec>
          <title>VR and AR Technologies</title>
          <p>For the recent past and as this review shows, more VR technologies (5/7, 71%) have been the focus of research in relation to rehabilitation compared with AR technologies (2/7, 29%).</p>
          <p>In home-based rehabilitation, VR and AR are used to improve physical functioning [<xref ref-type="bibr" rid="ref93">93</xref>], balance [<xref ref-type="bibr" rid="ref161">161</xref>] and anxiety [<xref ref-type="bibr" rid="ref162">162</xref>] in older individuals and people with neurological diseases. It was further revealed that VR is used by people with vestibular dysfunction to improve balance and postural control [<xref ref-type="bibr" rid="ref96">96</xref>].</p>
          <p>VR technologies were mostly used in combination with games that had not been developed for rehabilitation purposes, with the exception of 6 studies [<xref ref-type="bibr" rid="ref161">161</xref>-<xref ref-type="bibr" rid="ref166">166</xref>]. In the included studies, AR was used in combination with other devices, such as a robotic glove [<xref ref-type="bibr" rid="ref167">167</xref>] or motion-capturing devices [<xref ref-type="bibr" rid="ref168">168</xref>], to display an avatar on a screen, allowing clients to see their own movements. All software applications used for AR were developed for research purposes.</p>
          <p>In 1 study [<xref ref-type="bibr" rid="ref167">167</xref>], AR was used as a mirror therapy in combination with a robotic glove to improve the motor function of paretic limbs in clients after stroke. Participants saw a mirror image of themselves on a screen, with the paralyzed arm being mimicked by the virtual arm. They were instructed to perform tasks by first moving the uninjured arm and then the paralyzed arm—the animation of the virtual arm—was triggered by signals from markers on the glove.</p>
          <p>In addition to VR and AR, stakeholders added “Mixed reality” and “Digital twins” as a further trend in rehabilitation. Mixed reality is the merging of real and virtual worlds to produce new environments and visualizations in which physical and digital objects coexist and interact in real time. It includes VR and AR and thus represents the entire spectrum between the physical and digital worlds [<xref ref-type="bibr" rid="ref38">38</xref>]. A digital twin is a digital representation of tools, people, processes, and systems. In rehabilitation, digital twins are used to create digital representations of health-related data, such as data regarding hospital environments, laboratory results, and human physiology, through computer models [<xref ref-type="bibr" rid="ref169">169</xref>]. No application of digital twins in home-based rehabilitation has been reported. However, digital twins are not yet applicable in home-based settings.</p>
          <p>Currently, there is a lack of strong evidence supporting the use of VR and AR for rehabilitation [<xref ref-type="bibr" rid="ref49">49</xref>]. Stakeholders summarized that VR emerged in the market for rehabilitation 10 years ago and that the use of VR had been rather limited in the past because of its low usability. They further indicated that AR had greater potential than VR.</p>
        </sec>
        <sec>
          <title>Digital and Mobile Apps</title>
          <p>In this study, we identified 3 subcategories within the 26 reviews regarding digital and mobile apps: apps (19/43, 44%), web-based programs (17/43, 40%), and videoconference systems (7/43, 16%). The large number of published papers in this area illustrates their broad use in rehabilitation.</p>
          <p>Apps, web-based programs, and videoconference systems can be used for remote and home-based rehabilitation as adjuncts to face-to-face therapy or to replace some parts of it. It is noticeable that the use of these technologies is not limited to certain target groups, rather the client must fulfill some preconditions to use these technologies, such as access to the internet, mobile devices, or computers, as well as possessing necessary skills.</p>
          <p>Apps and web-based programs are used as assessments, specifically providing questionnaires via apps, or delivering guidance regarding assessments, or measuring movement through special sensors embedded in a smartphone [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref106">106</xref>,<xref ref-type="bibr" rid="ref170">170</xref>-<xref ref-type="bibr" rid="ref172">172</xref>]. These technologies can promote physical activity; improve physical functioning, mobility, and language and speech skills; and provide secondary prevention through exercises and (real-time) feedback, information, (self-) monitoring, and reminder functions [<xref ref-type="bibr" rid="ref105">105</xref>,<xref ref-type="bibr" rid="ref111">111</xref>,<xref ref-type="bibr" rid="ref114">114</xref>].</p>
          <p>Moreover, these technologies are used to improve cognitive functions [<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref173">173</xref>] and provide psychological support [<xref ref-type="bibr" rid="ref102">102</xref>]. Two articles [<xref ref-type="bibr" rid="ref174">174</xref>,<xref ref-type="bibr" rid="ref175">175</xref>] additionally described the function of web-based programs to improve balance, strength, mobility, and postural control of people with MS by providing physical exercise.</p>
          <p>Apps and web-based programs can help improve self-management and encourage a healthy lifestyle, rehabilitation, and adherence through individual goal setting, displaying rehabilitation progress, showing motivational messages, providing educational modules, and enabling symptom recording and social support [<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref108">108</xref>,<xref ref-type="bibr" rid="ref109">109</xref>,<xref ref-type="bibr" rid="ref112">112</xref>].</p>
          <p>Digital and mobile apps can further offer the possibility to connect with other people and become part of a social support community [<xref ref-type="bibr" rid="ref176">176</xref>].</p>
          <p>Stakeholders have criticized the lack of a solution that combines all the requirements of the rehabilitation process in one holistic approach. Even if the applications are available at a low price, the stakeholders emphasized that equal access to the internet and hardware should be ensured to decrease social inequality. They also expressed concerns that some clients may be excluded because they did not have the required competences and skills. Appropriate support is required for these clients. Furthermore, stakeholders have critically noted that digital and mobile apps encourage the replacement of face-to-face interventions, which they believe represents a clear disadvantage in terms of the outcomes of the rehabilitation process. In addition to all the benefits and limitations of digital and mobile apps, stakeholders identified this technology as one of the trends in the future health care sector.</p>
        </sec>
        <sec>
          <title>IoT Principles</title>
          <p>In total, 4 reviews explored the functionality of IoT principles.</p>
          <p>In rehabilitation, the IoT is beneficial for the collection of clients’ data through various technologies. These data can be sent to health care professionals to monitor clients’ health in their normal environment. In this manner, data can be collected to provide a complete picture of clients without blind spots. This information can be used to make medical decisions and treatment plans.</p>
          <p>IoT approaches include smart homes and ambient-assisted living (AAL). A smart home is a residence equipped with smart technologies aimed at providing tailored services to clients [<xref ref-type="bibr" rid="ref177">177</xref>]. AAL can be defined as the use of information and communication technologies in a person’s daily living and work environment [<xref ref-type="bibr" rid="ref178">178</xref>]. Smart homes and AAL make it possible to monitor and support residents in ADLs or create a safe environment, which can enhance quality of life and promote independent living. For example, in 1 project [<xref ref-type="bibr" rid="ref179">179</xref>], the client’s house was equipped with intelligent sensors to monitor the client and provide reminder to perform tasks such as taking medication or resting.</p>
          <p>Piau et al [<xref ref-type="bibr" rid="ref58">58</xref>] raised the question of whether the principles of smart homes can be applied to detect mild cognitive impairment or dementia in older individuals. For this purpose, data were gathered through either digital biomarkers, such as passive sensors, that were installed in homes (motion, light, temperature, and activity sensors) or wearables. Data from dedicated or purposive technological solutions can be used to monitor a client’s activities. Nevertheless, the authors concluded that most technologies were far removed from everyday life experiences and were not sufficiently mature for use under nonoptimal or uncontrolled conditions.</p>
          <p>Stakeholders emphasized the complexity of using the devices and high costs of the technologies, as well as expenses for installation, repair, and maintenance, as further barriers to implementing smart homes [<xref ref-type="bibr" rid="ref177">177</xref>].</p>
          <p>Referring to IoT, another approach that could benefit rehabilitation is living labs. The term “living labs” refers to the use of sensors to objectively record and evaluate people’s behavior and physical functioning without interruption over a long period [<xref ref-type="bibr" rid="ref123">123</xref>]. Personal or ambient technologies can be used for this purpose. Personal technologies include wearables that are attached to clothing or rest on the skin, such as smart watches or bracelets. Ambient technologies are placed in a client’s home, such as cameras and pressure and motion sensors, which are almost not perceived during use. These technologies can record various vital parameters, as well as collect information about physical activity, muscle activity, falls, and sleeping behavior.</p>
          <p>Stakeholders emphasized the benefits of linking the digital and physical worlds through IoT to enable a holistic approach to rehabilitation. In contrast, stakeholders have stated that clients often have great fears about the use of these technologies with an IoT approach owing to lack of safety.</p>
        </sec>
        <sec>
          <title>AI and Machine Learning</title>
          <p>In total, 4 reviews describing the principles of AI were included. In addition, 13 articles were selected to explore its use in rehabilitation with machine learning processes.</p>
          <p>AI and machine learning processes can be used as diagnostic and prognostic tools in rehabilitation. Abdollahi et al [<xref ref-type="bibr" rid="ref124">124</xref>] used a wearable system of sensors (IMUs) and machine learning processes to classify clients with nonspecific low back pain into subgroups according to quantitative kinematic data, for example, trunk motion– and balance-related measures. On the basis of this home assessment, a personalized rehabilitation plan was created following practical guidelines.</p>
          <p>Similarly, several articles have developed a home-based monitoring system based on AI and machine learning for use in executing a rehabilitation plan, even in the absence of a rehabilitation professional. For example, Chae et al [<xref ref-type="bibr" rid="ref127">127</xref>] developed a home-based rehabilitation system on a smartwatch, as well as an app and AI processes that can recognize and record the type and frequency of rehabilitation exercises conducted by the client. This can facilitate participation in home training and improve the functional scores of patients with chronic stroke. Lydakis et al [<xref ref-type="bibr" rid="ref131">131</xref>] designed a system of wearable glasses and smart bracelets to provide interactive corrective feedback to clients with neurological diseases in home settings.</p>
          <p>Chatbots and conversational agents are key technologies for AI and machine learning processes in rehabilitation. They could be based on AI and machine learning processes that simulate and process human conversations. They enable communication via text or audio on websites, mobile apps, or telephone [<xref ref-type="bibr" rid="ref137">137</xref>].</p>
          <p>Vaidyam et al [<xref ref-type="bibr" rid="ref137">137</xref>] further identified the potential of chatbots for use in psychoeducation and for encouraging self-adherence by providing information and motivation. The RCTs performed by Fitzpatrick et al [<xref ref-type="bibr" rid="ref180">180</xref>] and Fulmer et al [<xref ref-type="bibr" rid="ref99">99</xref>] reported health-related outcomes. They found that interaction with conversational agents led to decreased symptoms of depression and anxiety compared with the control groups.</p>
          <p>In their reviews, Schachner et al [<xref ref-type="bibr" rid="ref139">139</xref>] and Vaidyam et al [<xref ref-type="bibr" rid="ref137">137</xref>] found that the acceptance rating of conversational agents and chatbots was positive, suggesting that they would be effective and enjoyable tools for use in rehabilitation.</p>
          <p>Virtual human technology is based on AI and machine learning processes and used in rehabilitation. Virtual humans are computer-generated cartoon-like characters that have the ability to initiate and respond to verbal and nonverbal communications. The use of virtual humans in assisted care has mainly been implemented for healthy participants [<xref ref-type="bibr" rid="ref181">181</xref>-<xref ref-type="bibr" rid="ref183">183</xref>], with the aim of improving their health behaviors and reducing risk factors or physical inactivity. Furthermore, they have been used to provide advice and serve as motivators to increase physical activity in older individuals [<xref ref-type="bibr" rid="ref184">184</xref>].</p>
          <p>From a systemic perspective, the stakeholders expressed that AI and machine learning processes are the most relevant technologies for the future. AI and machine learning processes define future opportunities in the rehabilitation sector because they enable evidence to be generated based on the data collected. This can lead to resource optimization for the client and the health care system. However, stakeholders have stated that technologies such as chatbots and conversational agents have not yet been sufficiently developed for use in rehabilitation. Most of the work is still in the pilot phase, and the effectiveness of the technology has not yet been verified [<xref ref-type="bibr" rid="ref139">139</xref>].</p>
        </sec>
      </sec>
      <sec>
        <title>Research Question 3: Influence of COVID-19 on the Development of DR</title>
        <p>The 3-year pandemic (with May 5, 2023, as the end) has changed many rehabilitation processes for clients and health care professionals. To present the influence of the COVID-19 pandemic on DR, 40 records were included.</p>
        <p>To continue rehabilitation during the pandemic, remote digitally driven rehabilitation approaches, such as videoconferencing, apps, and web-based programs, were frequently used in practice. However, the crisis did not lead to the development of new DR technologies but rather to an increased use of technologies that were already on the market.</p>
        <p>This has led to more experiences with DR among clients, health care professionals, and health care providers. Clients accepted DR remotely as a substitute for face-to-face therapy during the pandemic [<xref ref-type="bibr" rid="ref110">110</xref>,<xref ref-type="bibr" rid="ref185">185</xref>-<xref ref-type="bibr" rid="ref188">188</xref>]. However, they also identified barriers to the use of technologies [<xref ref-type="bibr" rid="ref186">186</xref>,<xref ref-type="bibr" rid="ref188">188</xref>,<xref ref-type="bibr" rid="ref189">189</xref>]. To increase clients’ adoption, recommendations have been developed [<xref ref-type="bibr" rid="ref110">110</xref>]. Because many health care professionals are not trained to use virtual approaches in low-income countries [<xref ref-type="bibr" rid="ref190">190</xref>], as well as in industrialized countries [<xref ref-type="bibr" rid="ref191">191</xref>], additional training was offered to build competences in this area. Bernocchi et al [<xref ref-type="bibr" rid="ref192">192</xref>] further stated that not only clients but also health care professionals require adequate training to use digital approaches.</p>
        <p>The pandemic has led to an increased awareness of the need to develop further digital health measures (eg, digital vaccination certificate, digital sick note, improvement of digital tools, and simplified access to digital processing). In many countries, efforts have been made to implement digital solutions in the health care sector or help meet the preconditions for their use. However, the COVID-19 pandemic acted as an additional driver in the implementation of these applications. This was supported by political measures such as the softening of strict guidelines, which made it possible to launch and use digital solutions even without proof of their effectiveness [<xref ref-type="bibr" rid="ref193">193</xref>]. However, clients have expressed concerns regarding their effectiveness and safety [<xref ref-type="bibr" rid="ref194">194</xref>].</p>
        <p>In addition, in some countries (Austria and Germany), videoconference (therapy via videoconferencing) was legally approved, considering individual requirements, such as a specific diagnosis, the confirmation of the service provided, safe technical equipment, and a positive prognosis regarding the success of the application [<xref ref-type="bibr" rid="ref195">195</xref>,<xref ref-type="bibr" rid="ref196">196</xref>]. In Germany, this permission remains permanent regardless of the pandemic situation [<xref ref-type="bibr" rid="ref197">197</xref>].</p>
        <p>However, the rapid implementation has also led to the frequent implementation of incomplete solutions that have met the clients’ short-term needs but are not sustainable in the long term, as pointed out by stakeholders. In addition, evaluations of the measures have been less rigorous or have not been conducted, leading to the risk of perpetuating rapidly implemented solutions after the pandemic [<xref ref-type="bibr" rid="ref193">193</xref>].</p>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>This scoping review revealed various digital technologies intended for use in home-based rehabilitation. Trends were identified, and the advantages and disadvantages of each technology were presented. In addition, the influences of the pandemic on the development of DR were shown.</p>
        <p>The findings of this review reveal that sensors, robotic devices, gamification, VR and AR, and digital and mobile apps are already widely used in home-based rehabilitation. However, AI and machine learning, exoskeletons, and digital and mobile apps represent emerging trends in rehabilitation. Compared with the other identified technologies, VR, AR, and robotics cannot be used independently for home-based rehabilitation for usability and safety reasons. Thus, there is a need to develop sufficient and feasible DR practices that demonstrate clinically relevant effectiveness. Furthermore, we discovered that the COVID-19 pandemic has led to an increased use of digital technologies in a remote approach, especially apps, web-based programs, and videoconferencing, but not to the development of new technologies. Clients and health care professionals accepted this approach during the pandemic, but they also expressed concerns about it. The pandemic acted as a driver for implementing remote approaches for health care systems. However, sustainable solutions that can be applied even after the pandemic should be implemented.</p>
        <p>One major finding was that the relevance of AI and machine learning will increase in the field of rehabilitation in the future, especially for diagnostic procedures, decision-making, and the development of client-centered care, even though they are not yet broadly applied in rehabilitation. Furthermore, it was found that AI, machine learning, and digital and mobile apps would be essential to process and optimize resources in the health care sector. This finding is consistent with that in the current literature. For example, Hamet and Trembley [<xref ref-type="bibr" rid="ref198">198</xref>] stated that electronic medical or health records are essential tools for use in personalized medicine, early detection, and targeted prevention, with the aim of increasing their clinical value and decreasing health costs. Moreover, Róman-Belmonte et al [<xref ref-type="bibr" rid="ref199">199</xref>], who investigated the influence of AI on musculoskeletal disorders, highlighted that AI can produce a paradigm shift in musculoskeletal health, a move from descriptive to predictive medicine.</p>
        <p>Nevertheless, there are challenges that need to be overcome when applying AI and machine learning widely in the health care sector. Jiang et al [<xref ref-type="bibr" rid="ref200">200</xref>] report a lack of ethical and legal supervision. No globally unified laws or regulations regarding the application of AI in medicine are currently in place to standardize the behavior of practitioners [<xref ref-type="bibr" rid="ref200">200</xref>]. In addition to ethical and legal issues, one major challenge is the clear need for a standardized, comparative evaluation of the effects of AI on health indicators and measures of changes in psychological and physical status, side effects, and outcomes [<xref ref-type="bibr" rid="ref198">198</xref>]. The findings regarding acceptance were incoherent. Health care professionals support the application of AI in rehabilitation and desire training for its application. However, people who are less well informed about AI fear being replaced by this technology, often because of a lack of knowledge about AI [<xref ref-type="bibr" rid="ref200">200</xref>]. Therefore, it is important to outline the benefits and barriers of using AI for rehabilitation within society.</p>
        <p>One further result was that technologies such as gamification, VR and AR, and digital and mobile apps that are already used in home-based rehabilitation have the potential to improve client adherence and motivation. Similarly, approaches based on IoT can increase client participation in the rehabilitation process because they allow self-monitoring; thus, client self-management can be increased. This represents an important factor for successful therapy of chronic diseases to improve quality of life and reduce the use of health care resources [<xref ref-type="bibr" rid="ref201">201</xref>].</p>
        <p>This study revealed that most technologies could be used in home-based rehabilitation without the presence of health care professionals. The emerging developments in the design and possibility of asynchronous or synchronous monitoring via apps, web-based programs, or videoconferencing make the remote rehabilitation approach possible. In other studies [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref202">202</xref>], the results showed that the independent use of VR and AR technologies and robotics in a home setting is limited owing to low usability and safety concerns. Clients with disabilities may require assistance in attaching or using the device or face the risk of harming themselves when excessive force is transferred to the body. However, to provide independent, usable, and safe rehabilitation at home, trained caregivers supporting the clients [<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref203">203</xref>] or the construction of the rehabilitation device have the ability to overcome this challenge. For example, attachment mechanisms could be designed to enable the client to don and doff the device [<xref ref-type="bibr" rid="ref159">159</xref>]. Furthermore, Kim et al [<xref ref-type="bibr" rid="ref204">204</xref>] used emergency stop buttons and added safety features limiting ROM and joint velocity and stopping the robot in case of excessive force and torque interaction.</p>
        <p>In order to offer client-friendly rehabilitation in the home setting, sufficient space for the equipment must also be ensured. Furthermore, the technical equipment needs to meet requirements such as access to the internet or a digital and mobile device, and the costs of purchasing, repairing, and maintaining the technology need to be low [<xref ref-type="bibr" rid="ref62">62</xref>] because such costs are not always covered by health insurance funds.</p>
        <p>In addition to the safety and usability factors, the use of DR should be based on an individual rehabilitation goal, considering the motivation of clients and health care professionals to use technologies and the possibility of receiving support when using such technologies [<xref ref-type="bibr" rid="ref205">205</xref>]. Furthermore, individual physical conditions should be considered, which may affect the use of the selected therapy (grade of dementia, disability of vision or hearing, and degree of impairment). It must be noted that Cottrell and Russell [<xref ref-type="bibr" rid="ref205">205</xref>] limited their recommendations to videoconferencing in physiotherapy practice. Given that the technology must be customized to the client’s body, these recommendations can also be considered when using other technologies.</p>
        <p>Another major finding is that the effectiveness of many technologies has not yet been confirmed scientifically. Several studies have described projects in which the technology is currently under development or tested in laboratory settings. However, it can also be seen that 221 RCTs referring to DR are already registered via ClinicalTrials.gov for 2021 and 2022 (September 15, 2022). Because many technologies have only been used under controlled conditions, their application in daily life cannot be assessed.</p>
        <p>In addition, we found that feasible approaches to the implementation and integration of digital technologies for the rehabilitation process are lacking. Accordingly, it is essential to consider not only the effectiveness of the intervention in terms of dedicated outcomes, the design of the intervention itself, and the characteristics of individuals but also the setting in which the approach will be applied, the process of implementation, and factors influenced by policies and government regulations [<xref ref-type="bibr" rid="ref206">206</xref>].</p>
        <p>Therefore, studies are required that present an effective and valid concept that can enable clients and health care professionals to apply digital technologies for (home-based) rehabilitation. This includes the presentation of plans for the modus of DR (blended therapy or replacing face-to-face therapy), the reimbursement of health care professionals, and cost coverage for the technologies needed by clients and rehabilitation units. Other issues must be addressed for a feasible implementation, such as privacy compliance, data protection, insurance coverage, and the assumption of responsibility and liability if harm occurs during remote or unsupervised rehabilitation.</p>
        <p>The social distancing regulations enacted during the COVID-19 pandemic caused many clients and health care professionals to use DR, especially videoconferencing, apps, and web-based programs. Clients and professionals described their relatively high level of DR positivity along with improvements over the course of the COVID-19 lockdown. However, the question of whether this therapy model will continue to be accepted without exceptional circumstances remains.</p>
        <p>The literature shows contrary results regarding the acceptance of digital interventions by clients and health care professionals [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref207">207</xref>]. However, it is noteworthy that many terminologies exist for <italic>Digital Rehabilitation</italic> that are associated with various technologies. It is likely that the acceptance rates of different technologies vary, which does not allow for a general statement about their acceptance among clients and health care professionals.</p>
        <p>Through the COVID-19 pandemic, more training opportunities for health care professionals were offered to allow them to gain competence in the field of DR. To be adequately prepared for working life and systematize the acquisition of competencies, health care professionals should already have acquired the necessary skills in higher education. Because DR technologies have already been implemented in rehabilitation, it is crucial that health care professionals are sensitized to the possibility of integrating digital options, acquire useful competencies, and have the ability to recognize which clients will benefit from this approach and then provide adequate assistance to them.</p>
        <p>Although the pandemic was, in many ways, a driver of the use of DR, it also led to the rapid introduction of solutions that were not based on an efficient concept and left many questions unanswered with regard to realistic implementation. Therefore, careful planning with a phased, linear implementation approach is crucial for establishing sustainable DR practices that will last beyond the pandemic and have the potential to meet the challenges of rehabilitation in the future [<xref ref-type="bibr" rid="ref208">208</xref>].</p>
        <p>The results of this study paint a very broad picture of existing and emerging technologies in rehabilitation because a large number of records were included in the analyses, which were not limited to a specific target group or rehabilitation outcomes. The results derived from the scientific databases were complemented by a search of the gray literature. Through a meeting with key stakeholders, insights were gained beyond those reported in the literature. In addition to health care professionals, politicians, experts in the field of digitalization in rehabilitation, and clients with experience or a specific interest in DR were included.</p>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>Bibliometric and co-occurrence analyses were performed with a minimum of 10 occurrences per keyword. This may have influenced the completeness of the representation of technologies if newer technologies occurred fewer than 10 times throughout the data set. However, the stakeholder meeting served to close this gap. Moreover, we did not weigh the strength of the evidence from all papers or appraise the efficacy of the approaches, which would have been beyond the scope of this review. In addition, new technologies may have been developed in the meantime and were not presented here because of the rapid development of the market.</p>
        <p>In the search for relevant literature, we used the word “rehabilitation” and not other terms commonly used in the context, such as “therapy,” “training,” “intervention,” or “treatment,” because we wanted to stick to the concept of rehabilitation, which implies a multimodal, collaborative, and patient-centered process rather than the stand-alone interventions suggested by those terms [<xref ref-type="bibr" rid="ref209">209</xref>]. However, it resulted in few articles being included related to mental and psychosocial disorders, despite the Cochrane definition of rehabilitation states that rehabilitation also includes people with mental problems [<xref ref-type="bibr" rid="ref209">209</xref>]. Thus, rehabilitation seems to be still more closely associated with the improvement or optimization of physical functions.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>These findings reflect the growing interest in the use of digital technologies in rehabilitation. Multiple tools are already available and implemented for home-based rehabilitation; however, there are some limitations to their use, such as low usability, safety concerns, ethical challenges, and a lack of efficacy and legal frameworks. DR implementation should be based on the clients’ goals and motivation. AI and machine learning could be of particular interest in redesigning rehabilitation to address future challenges in the rehabilitation sector.</p>
        <p>On the one hand, the pandemic acted as a driver for the application and acceptance of existing digital solutions in rehabilitation. On the other hand, digital solutions that only met the requirements of the clients during the pandemic were implemented. The results of this research reflect the need for feasible and effective approaches to implement DR sufficiently to meet clients’ needs and adhere to framework conditions to be sustained apart from exceptional situations.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist.</p>
        <media xlink:href="rehab_v10i1e43615_app1.pdf" xlink:title="PDF File  (Adobe PDF File), 506 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>Search strategies.</p>
        <media xlink:href="rehab_v10i1e43615_app2.docx" xlink:title="DOCX File , 16 KB"/>
      </supplementary-material>
      <supplementary-material id="app3">
        <label>Multimedia Appendix 3</label>
        <p>Definitions.</p>
        <media xlink:href="rehab_v10i1e43615_app3.docx" xlink:title="DOCX File , 19 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">AAL</term>
          <def>
            <p>ambient-assisted living</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">ADL</term>
          <def>
            <p>activity of daily living</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">AI</term>
          <def>
            <p>artificial intelligence</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">AR</term>
          <def>
            <p>augmented reality</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">BCI</term>
          <def>
            <p>brain-computer interface</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">COPD</term>
          <def>
            <p>chronic obstructive pulmonary disease</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb7">DIRENE</term>
          <def>
            <p>Competences for the new era of user-driven Digital Rehabilitation</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb8">DR</term>
          <def>
            <p>digital rehabilitation</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb9">IMU</term>
          <def>
            <p>inertial measurement unit</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb10">IoT</term>
          <def>
            <p>Internet of Things</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb11">MS</term>
          <def>
            <p>multiple sclerosis</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb12">PRISMA-ScR</term>
          <def>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb13">RCT</term>
          <def>
            <p>randomized controlled trial</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb14">RIS</term>
          <def>
            <p>Research Information Systems</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb15">VR</term>
          <def>
            <p>virtual reality</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>The authors would like to thank all the researchers whose work was included in this review. The research reported in this publication was part of the project “Competences for the new era of user-driven Digital Rehabilitation (DIRENE),” which was supported by the Erasmus+ program of the European Commission (project number: 2020-1-FI01-KA226-HE-092634). More information about the Erasmus+ programs is available on the web [<xref ref-type="bibr" rid="ref210">210</xref>]. The European Commission is not responsible for the content of this publication. The content is the sole responsibility of the authors.</p>
    </ack>
    <notes>
      <sec>
        <title>Data Availability</title>
        <p>The data sets generated and analyzed during this study are available from the corresponding author upon reasonable request.</p>
      </sec>
    </notes>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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