We systematically searched the literature in the PubMed and Medline databases, British Medical Journal, Oxford Journals, Biomed Central, and CINAHL using the Medical Subject Headings (MeSH) “telerehabilitation,” “telemedicine,” and “rehabilitation,” as well as “disabling pathologies” . Parameters applied were English language, at least one keyword corresponding to the search terms in the title or abstract, and study based on the evaluation of clinical trials. An additional evaluation criterion was the publication of articles in peer-reviewed journals. The search was carried out in 2016 for the years January 1996 to January 2016. Moreover, we selected and examined 45 books and other online materials through Google search, university of Camerino E-database, and the central library of University of Camerino. We retrieved more than 400 articles on telerehabilitation or related topics. A further analysis performed by 2 researchers independently reading article titles and abstracts reduced the results to less than the 25% of articles.

We excluded studies or other materials published before 1996 from our analysis. This is because, as Figure 1 shows, the first effective telerehabilitation procedures started in 1998. Therefore, the selected articles were published between 1996 and 2016. We also excluded articles published in nonpeer-reviewed journals, as well as pilot studies, due to the small number of patients investigated. Only English-language articles were selected. Finally, we discarded articles without the terms telerehabilitation, disabling pathologies, telemedicine, or rehabilitation in the title or keywords.

We evaluated the relevant articles with the standard criteria of the Newcastle-Ottawa Scale for assessing the quality of nonrandomized studies in meta-analyses [16]. Overall study quality was defined as poor (score 0-4), moderate (5-6), or good (7-9). The score was based on the following filters that could be attributed to a review article: comparability, and desired outcome. In addition, we analyzed various parameters of each article. The scores depended on these parameters.

The literature search identified 488 abstracts, 127 of which we analyzed in detail. Among these 127 articles, we excluded 100 in a full-text analysis (Figure 2 [17]). The search analysis showed that, although all these articles matched with the keywords we used, most of them were pilot studies evaluating the response of the system in the real environment in a small sample group of patients. We did not discard these articles because pilot studies are also a valuable source of information, but we considered them as an experience in relation to the patients involved. Finally, we chose only a few of articles (n=27) to assess applications of telerehabilitation to meet patients’ needs in everyday life [18,19].

From our literature analysis, we identified that telerehabilitation was used primarily in cardiac, neurological, and physiotherapy rehabilitation. Table 1 summarizes data derived from the literature and supplemented by additional information when available [1-15,18-29].

In chronic cardiac diseases, rehabilitation is one of the main tools used to improve the quality of life of patients, along with a drastic reduction of cardiac risk factors, mainly through lifestyle changes. Inpatient rehabilitation is in general effective and efficient, whereas in outpatients the quality of rehabilitation is limited. Only 13% to 40% of the total cardiac patient population in Germany performed cardiac rehabilitation in a supervised and controlled-phase program [14]. Some studies showed that at least 5 to 30 minutes of aerobic sessions per week reduce cardiac risk factors [20]. Patients do not join supervised and controlled-phase rehabilitation programs due to scheduling conflicts, difficulties in reaching the training phase, and a reluctance to perform the exercise in a group. Another study showed that home-based telemonitored cardiac rehabilitation (HTCR) is a new method of rehabilitation for stable heart failure patients [21]. For at-home exercise, transtelephonic ECG could be a good substitute for outpatient visits [22] and probably HTCR produces quality-of-life improvements similar to those obtained by standard outpatient-based cardiac rehabilitation [23].

An example of telerehabilitation applied to cardiovascular diseases is the SAPHIRE system [14]. It consists of a bicycle with a touch screen and wireless sensors to check the patients’ ECG, blood pressure, and oxygen saturation in real time. At the hospital, the supervising staff can connect remotely to the patient’s computer touch screen to customize the exercises based on the results of a previous exercise stress test. They can monitor the patient’s health condition in real time during the rehabilitation, and they can stop the exercises if abnormal sensors values are detected. In particular, the system has three different training forms: constant load, intervals, and heart rate control. If any limits are exceeded, the patient is alerted through an icon to reduce the load or to immediately abort the exercises. The SAPHIRE system was used in 4 patients with 13 staff members. During the experimental phase, no serious events related to heart disease occurred, but some difficulties were observed regarding sensor operation. In the 39 training sessions completed, in 27% of them the ECG connection could not be established and in 23% blood pressure measurement failed.

The more important advantage of this kind of telerehabilitation system is common to other telehealth systems. Patients can follow their rehabilitation program at a distance (eg, at home) saving time and money, and avoiding unnecessary travel and discomfort to the patient. The disadvantages are also common among different telerehabilitation systems. These include limited flexibility in the use of the various medical devices appropriate to patients’ differing needs.

In the case of neurological diseases such as brain injury or cognitive problems, the best rehabilitation for patients is to stimulate the brain with adequate environmental interactions. Probably due to the short history of neurological rehabilitation techniques, neurological telerehabilitation approaches are not clearly defined at this point and have no concrete theoretical bases [24]. Recent research in human-computer interfaces has improved the effectiveness of virtual reality. Virtual reality consists of simulations through dedicated machines such as personal computers with specific graphical features of a real environment. The machine could be interfaced with devices such as robotic arms, robotic legs, data gloves, and smart glasses. Such smart devices can be used in a 3-dimensional environment simulation, and they can allow for a greater sense of immersion in the virtual environment [10].

The first conference on virtual reality applied to medicine was the Medicine Meets Virtual Reality conference [25]. Advantages of this new type of approach over standard care were discussed. The positive results encouraged the use of this smart technology. Performing exercises inside a laboratory (ie, in front of a computer) avoids the unnecessary risk that comes with performing the same exercises in a real and dangerous environment, can establish the simulated environment in relation to the patient’s condition, and optimizes the difficulty of the environment according to the patient’s neurological severity [26].

Health care treatment closer to the needs of the specific pathologies of the patient improves the quality of life and often decreases the duration of treatment. It has been shown that virtual reality can be used for the assessment and rehabilitation of specific disabilities resulting from brain injury, executive dysfunction, memory impairments, spatial disability, attention deficits, and unilateral visual neglect. A virtual urban environment for the treatment of 27 patients with moderate and severe brain injuries was developed in which patients needed to navigate in the simulator. However, this study showed no improvement due to the number of repetitions [24].

Another example of a telerehabilitation system is the Rehab@Home framework used to perform rehabilitation in the domestic setting for stroke patients [8]. The framework consists of instrumented insoles connected wirelessly to a third-generation tablet computer, a server, and a graphic Web interface for medical experts. Rehabilitation progress is automatically analyzed after assessment tests are executed in the tablet computer. Both the systems (Rehab@Home, virtual urban environment) were accepted by patients and doctors because of good results obtained. Perhaps the systems described above will not be used widely in the future, but they will contribute to improve these approaches in the future, with better cardiac telerehabilitation applications.

A telerehabilitation system was applied to 99 poststroke patients to evaluate their quality of life. The authors observed a statistically significant change in both interventions (normal and robotic rehabilitations). Actually, both modalities were effective in improving quality of life and depression outcomes for participants at less than 6 months after their stroke. The goal of this study was to obtain better results for robotic rehabilitation, but the findings obtained did not show significant differences between the 2 groups [27].

A telerehabilitation project called H-CAD was developed from 2003 to 2005. H-CAD is a system for patients with multiple sclerosis, stroke, or traumatic brain injury for performing upper limb rehabilitation treatment, at home. A help desk was developed to guide the patients in developing a proper exercise regimen by evaluating the performance periodically. Patients had the possibility to interact with doctors at the hospital through a teleconferencing system. The process was carried out in 2 test phases. The first phase was to test the results of the system with volunteers inside a hospital. The second phase was to test the system at home with ad hoc patients. The results were encouraging, and the doctors observed a marked improvement in patients using this system [3].

More recently, the use of a telerehabilitation approach in the management of patients with depression was studied [28]. Here, the authors used an Internet-mediated cognitive behavioral therapy (iCBT) system to treat depression remotely. Unfortunately, considering that depression is an important, modern, and widespread psychiatric disorder, these results were not conclusive [28]. Eventually an individual treatment design seems to be preferred, and elements of iCBT could be included as a complement when treating depression in primary care. These procedures may be economically important because they could relieve the overall treatment burden of depression.

Musculoskeletal disorders have a high impact on health care provision. A controlled study was conducted to assess the effectiveness of a telerehabilitation approach instead of standard face-to-face practice. A literature review analyzed 898 studies on the validity and reliability of Internet-based physiotherapy assessment for musculoskeletal disorders. Most of the telerehabilitation approaches were valid if they were applied for some physical diseases, except for lumbar spine posture, where the final score was not conclusive. In fact, results showed that the intervention had effectiveness scores from low to moderate [6].

Another study demonstrated the use of Microsoft Kinect, a motion-sensing input device, to detect patients’ posture and movement, and it enabled caregivers to develop custom exercise patterns for each patient. Tests confirmed that the intervention had several benefits, particularly in creating a customized physical exercise program for physical rehabilitation [7].

Like every technology, telerehabilitation has some advantages and disadvantages. In terms of advantages, home telerehabilitation systems are cost effective if the intervention is just used to monitor or evaluate patients during corrective therapy [14,29]. The possibility to stay in touch with telematic technologies allows patients with serious pathologies, such as severe cognitive deficits, to perform physiotherapy at home without having to make tiring journeys. In terms of disadvantages, a problem could be the loss of human contact (face-to-face interaction) with the doctor. Moreover, for each patient, system operators are required to optimize the teletherapy according to the type of disease, and sometimes this is not possible due to high costs.

This review evaluated different application fields of telerehabilitation, highlighting its benefits and drawbacks. In conclusion, this analysis has shown that telerehabilitation is a new and interesting field but, unfortunately at present, there are no standard procedures or protocols, and different telerehabilitation facilities are being used for pilot studies only. Herein, we suggest the need for further research to improve the electronic equipment and devices, and to make their application as flexible as possible. This approach should significantly increase the reliability and effectiveness of telerehabilitation equipment to treat specific patient problems. Furthermore, in this context, feedback from patients may be important to update rehabilitation techniques to improve the quality of the rehabilitation itself. On the other hand, an important aspect of the future success of telerehabilitation involves proper training of people involved in these new forms of intervention, which may lead to more effective rehabilitation.